{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC00662 is a long intergenic non‐coding RNA that has emerged as a multifunctional oncogenic regulator in a wide range of human cancers. Numerous independent studies have demonstrated that its expression is frequently up‐regulated in tumor tissues – including hepatocellular carcinoma, gastric cancer, lung cancer, prostate cancer, acute myeloid leukemia, chordoma, breast cancer, esophageal squamous cell carcinoma, melanoma, colorectal cancer, osteosarcoma, glioma, and bladder cancer – and that high levels of LINC00662 are consistently associated with aggressive clinicopathological features, poor prognosis, and resistance to chemotherapy or radiotherapy."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "32"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Mechanistically, LINC00662 exerts its oncogenic effects primarily through its function as a competing endogenous RNA (ceRNA). It sequesters and “sponges” various microRNAs – such as miR‐15a, miR‐16, miR‐107, miR‐497‐5p, miR‐320d, miR‐340‐5p, miR‐34a, miR‐144‐3p, miR‐103a‐3p, among others – which in turn leads to the de‐repression and up‐regulation of key downstream target genes (including, but not limited to, WNT3A, YAP1, Lin28, E2F1, CDC25A, HOXB2, ELK3, CEP55, Notch2, and others) that drive cell proliferation, migration, invasion, epithelial–mesenchymal transition (EMT), and metastasis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}, {"type": "fg_f", "ref": "4"}, {"type": "fg_f", "ref": "9"}, {"type": "fg_f", "ref": "12"}, {"type": "fg_fs", "start_ref": "21", "end_ref": "25"}, {"type": "fg_f", "ref": "30"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In addition, LINC00662 has been reported to influence a variety of oncogenic signaling pathways—notably the Wnt/β‐catenin, Hippo–YAP1, ERK, and p38 MAPK cascades—which further contribute to enhanced tumor cell proliferation, invasiveness, and maintenance of cancer stem cell properties."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "16", "end_ref": "20"}]}, {"type": "t", "text": " Some studies have also uncovered that LINC00662 can modulate the tumor microenvironment—for example, by promoting the secretion of factors that polarize macrophages toward a tumor‐promoting (M2) phenotype—and can affect cellular metabolism and even genomic methylation status via regulation of key metabolic enzymes and co‐factors.\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Beyond its role in classical oncogenic processes, LINC00662 has been implicated in additional pathological contexts. Its regulatory functions have been linked to blood–brain barrier permeability in Alzheimer’s disease"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "33"}]}, {"type": "t", "text": "and to aspects of radiosensitivity in osteosarcoma and oral squamous cell carcinoma."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}, {"type": "fg_f", "ref": "24"}]}, {"type": "t", "text": " Moreover, studies in reproductive biology indicate that LINC00662 is among a set of lncRNAs with differential expression during spermatogenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "34"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these findings highlight LINC00662 as a key oncogenic lncRNA whose multifaceted regulatory mechanisms—including its role as a microRNA sponge, its modulation of signal transduction pathways, and its interactions with RNA‐binding proteins—contribute to tumor initiation, progression, metastasis, and therapy resistance. Its widespread dysregulation across different malignancies underscores its potential as both a prognostic biomarker and a promising therapeutic target."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "10"}, {"type": "fg_fs", "start_ref": "12", "end_ref": "32"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Xiaohui Tian, Yuanyuan Wu, Yating Yang, et al. 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