{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Recent studies have begun to elucidate the role of the long intergenic non‐coding RNA LINC00663 in cancer. In glioma, for example, LINC00663 is significantly overexpressed in tumor tissues and cell lines compared with normal brain tissues and human astrocytes. High LINC00663 levels correlate with reduced overall survival, and experimental knockdown of LINC00663 markedly inhibits cell proliferation, migration, and invasion, an effect that appears to be mediated via downregulation of the AKT/mTOR signaling pathway."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In addition, analyses across various human tissues and cancer cell lines reveal that LINC00663 expression is notably prominent in the thyroid and uterus while being much lower in skeletal muscle, suggesting potential tissue‐specific functions. Furthermore, the discovery of multiple splice variants and a novel exonic region within LINC00663 indicates that its secondary structure and interaction with microRNAs are subject to complex regulation, which may contribute to its role in cancer biology."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " While additional studies—such as those focusing on uterine leiomyomata and breast cancer—have underscored the importance of comprehensive molecular signatures and the involvement of non‐coding RNAs in tumor pathogenesis"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ", the current findings collectively suggest that LINC00663 may exert a cancer‐promoting role by modulating key signaling pathways and through diverse regulatory mechanisms. Further investigations are warranted to fully elucidate its functional contributions across different malignancies.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Meichen Pan, Jingren Shi, Shangqi Yin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The Effect and Mechanism of LINC00663 on the Biological Behavior of Glioma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neurochem Res (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s11064-021-03311-3"}], "href": "https://doi.org/10.1007/s11064-021-03311-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33830405"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33830405"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Esra Bozgeyik, Yusuf Ziya Igci, Mevan F Sami Jacksi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A novel variable exonic region and differential expression of LINC00663 non-coding RNA in various cancer cell lines and normal human tissue samples."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Tumour Biol (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s13277-015-4782-3"}], "href": "https://doi.org/10.1007/s13277-015-4782-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26743782"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26743782"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Jennelle C Hodge, Peter J Park, Jonathan M Dreyfuss, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identifying the molecular signature of the interstitial deletion 7q subgroup of uterine leiomyomata using a paired analysis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genes Chromosomes Cancer (2009)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/gcc.20692"}], "href": "https://doi.org/10.1002/gcc.20692"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "19603527"}], "href": "https://pubmed.ncbi.nlm.nih.gov/19603527"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Bita Hassani, Mohammad Taheri, Yazdan Asgari, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression Analysis of Long Non-Coding RNAs Related With FOXM1, GATA3, FOXA1 and ESR1 in Breast Tissues."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Oncol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fonc.2021.671418"}], "href": "https://doi.org/10.3389/fonc.2021.671418"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34094972"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34094972"}]}]}]}