{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Recent studies have revealed that LINC00664 plays multifaceted roles in the regulation of gene expression in various pathological contexts. In oral squamous cell carcinoma (OSCC), LINC00664 is significantly upregulated and acts as an oncogenic factor that promotes cell proliferation, migration, invasion, and epithelial–mesenchymal transition (EMT) by engaging in a positive feedback loop with the transcription factor KLF9 via sponging of miR-411-5p, thereby contributing to tumor progression and poor patient prognosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In the context of cardiovascular disease, particularly myocardial fibrosis following acute myocardial infarction, LINC00664 has been implicated as a potential biomarker through its involvement in a competing endogenous RNA (ceRNA) network with hsa‑miR‑197‑3p and JAK2, suggesting a role in the fibrotic remodeling process."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Furthermore, integrative bioinformatics analyses in ovarian carcinoma have identified LINC00664 as one of the critical long noncoding RNAs whose aberrant expression is associated with an increased risk of recurrence, highlighting its potential as an independent prognostic marker."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Similarly, in colorectal cancer, inclusion of LINC00664 in an eight-lncRNA prognostic signature correlates with overall survival, possibly through regulation of oxygen metabolism–related processes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n These findings collectively underscore the diverse biological functions of LINC00664, ranging from modulation of ceRNA networks in cardiovascular pathology to the promotion of oncogenic processes in multiple tumor types, thereby identifying it as a promising candidate for further study as both a biomarker and a potential therapeutic target.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yikang He, Yangfan Ye, Wei Tian, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A Novel lncRNA Panel Related to Ferroptosis, Tumor Progression, and Microenvironment is a Robust Prognostic Indicator for Glioma Patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Cell Dev Biol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fcell.2021.788451"}], "href": "https://doi.org/10.3389/fcell.2021.788451"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34950662"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34950662"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Shuo Wang, Yuying Liu, Xitian Hu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of ceRNA (lncRNA-miRNA-mRNA) Regulatory Network in Myocardial Fibrosis After Acute Myocardial Infarction."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Gen Med (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2147/IJGM.S329391"}], "href": "https://doi.org/10.2147/IJGM.S329391"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34984022"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34984022"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Ying Chen, Fangfang Bi, Yuanyuan An, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of pathological grade and prognosis-associated lncRNA for ovarian cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biochem (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcb.28704"}], "href": "https://doi.org/10.1002/jcb.28704"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31034644"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31034644"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Lin Zhang, Shuo Chen, Boxue Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "An eight-long noncoding RNA expression signature for colorectal cancer patients' prognosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biochem (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcb.27847"}], "href": "https://doi.org/10.1002/jcb.27847"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30320902"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30320902"}]}]}]}