{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Long intergenic non‐coding RNA 00668 (LINC00668) has emerged as a prominent oncogenic player in a wide variety of human cancers. Multiple studies have consistently shown that LINC00668 is up‐regulated in malignancies including gastric cancer"}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": ", colorectal cancer"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ", non‐small cell lung cancer"}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "6", "end_ref": "8"}]}, {"type": "t", "text": ", hepatocellular carcinoma"}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "9", "end_ref": "11"}]}, {"type": "t", "text": ", glioma"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "12"}]}, {"type": "t", "text": ", as well as in breast"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "13"}]}, {"type": "t", "text": "and prostate cancers."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "15"}]}, {"type": "t", "text": " In gastric cancer, LINC00668 is directly induced by E2F1 and interacts with polycomb repressive complex 2 (PRC2) to epigenetically silence multiple cyclin‐dependent kinase inhibitors, thereby promoting cell cycle progression and tumor growth."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In colorectal cancer, it acts as a competing endogenous RNA (ceRNA) by sequestering miR‑188‑5p to de‐repress USP47, which enhances proliferation and migratory capacity."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " Similarly, in non‐small cell lung cancer, STAT3‐induced LINC00668 sponges miR‑193a to elevate KLF7 expression, thereby facilitating proliferation, migration, and invasion."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " In hepatocellular carcinoma and glioma, LINC00668 exerts its oncogenic effects through ceRNA mechanisms as well – for example, by binding miR‑532‑5p or miR‑518c‑3p to modulate the expression of YY1 and SOCS5, respectively."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}, {"type": "fg_f", "ref": "12"}]}, {"type": "t", "text": " In addition, LINC00668 promotes epithelial‐to‐mesenchymal transition (EMT) and metastasis in oral squamous cell carcinoma and lung squamous cell carcinoma by modulating VEGFA and Slug expression via sponging of miR‑297 and miR‑147a, respectively."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}, {"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": " Moreover, its involvement in enhancing self‐renewal and chemoresistance in breast cancer and its inclusion in prognostic long non‐coding RNA signatures further underscore its potential clinical relevance."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "13", "end_ref": "16"}]}, {"type": "t", "text": " Collectively, these findings indicate that LINC00668 is a key regulator of tumorigenic processes—including cell proliferation, invasion, metastasis, and EMT—across a spectrum of cancers, and highlight its promise as both a prognostic biomarker and a potential therapeutic target.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Erbao Zhang, Dandan Yin, Liang Han, et al. 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