{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC00671 is a long non‐coding RNA that exhibits tumor‐suppressive functions in several cancer types. In thyroid cancer, LINC00671 is negatively correlated with lactate dehydrogenase A (LDHA) expression, and its downregulation—exacerbated by hypoxia via STAT3 activation—results in enhanced glycolysis, tumor growth, and lung metastasis. Restoration of LINC00671 expression is associated with better clinical outcomes, suggesting that it plays an important role in dampening cancer progression by inhibiting LDHA and its downstream effects."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In pancreatic cancer, multiple independent studies have demonstrated that LINC00671 is expressed at low levels in tumor samples compared to normal tissue. Mechanistic studies indicate that overexpression of LINC00671 leads to inhibition of key oncogenic pathways, including the AKT, ERK, and epithelial‐mesenchymal transition (EMT) cascades, and is associated with reduced cell proliferation, invasion, and migration. This tumor‐suppressive function further correlates with improved patient prognosis"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "and is additionally supported by serum and tissue analyses where lower LINC00671 expression is indicative of advanced disease stages."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In renal cell carcinoma, reduced levels of LINC00671 have been linked to enhanced tumor proliferation, migration, and invasion. Functional experiments reinforce that LINC00671 overexpression suppresses these malignant phenotypes by regulating the miR‐221-5p/SOCS1 axis, with lower expression being associated with unfavorable clinicopathological features and shorter patient survival."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these findings underscore the critical role of LINC00671 as a tumor suppressor acting through diverse mechanisms—including metabolic regulation in thyroid cancer and modulation of signal transduction and EMT in pancreatic and renal cancers—highlighting its potential as a therapeutic target and prognostic biomarker.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Nan Huo, Rui Cong, Zhi-Jia Sun, et al. "}, {"type": "b", "children": [{"type": "t", "text": "STAT3/LINC00671 axis regulates papillary thyroid tumor growth and metastasis via LDHA-mediated glycolysis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Dis (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41419-021-04081-0"}], "href": "https://doi.org/10.1038/s41419-021-04081-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34404767"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34404767"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Shibin Qu, Kunwei Niu, Jianlin Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC00671 suppresses cell proliferation and metastasis in pancreatic cancer by inhibiting AKT and ERK signaling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Gene Ther (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41417-020-00213-4"}], "href": "https://doi.org/10.1038/s41417-020-00213-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32801328"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32801328"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Baogang Zhang, Changfeng Li, Zhixia Sun "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA LINC00346, LINC00578, LINC00673, LINC00671, LINC00261, and SNHG9 are novel prognostic markers for pancreatic cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Transl Res (2018)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30210701"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30210701"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Gang Jin, Haiyan Mi, Yunfei Ye, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC00671 inhibits renal cell cancer progression via regulating miR-221-5p/SOCS1 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Am J Transl Res (2021)"}]}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34377233"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34377233"}]}]}]}