{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Long intergenic non‐coding RNA 00678 (LINC00678) is emerging as a potential regulator of gene expression in neural contexts. Although neither abstract explicitly details the functions of LINC00678, observations from neurons derived from different induced pluripotent stem cell (iPSC) sources suggest that regulatory non‐coding RNAs may contribute to regional and developmental differences in gene expression—for instance, in the modulation of HOX gene family members and key transcription factors involved in forebrain development (see."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In addition, reviews of long non‐coding RNAs highlight that molecules like LINC00678 can influence gene expression through diverse mechanisms including interactions with histone-modifying complexes, transcription factors, and RNA molecules, thereby affecting both transcriptional and post‐transcriptional regulation (see."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Together, these findings support the notion that LINC00678 may play a multifaceted role in neural development and neuropsychiatric disease modeling by modulating complex regulatory networks essential for neuronal differentiation and cellular homeostasis.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Jian Chen, Mingyan Lin, John J Foxe, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Transcriptome comparison of human neurons generated using induced pluripotent stem cells derived from dental pulp and skin fibroblasts."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0075682"}], "href": "https://doi.org/10.1371/journal.pone.0075682"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24098394"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24098394"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Amanda Salviano-Silva, Sara Cristina Lobo-Alves, Rodrigo Coutinho de Almeida, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Besides Pathology: Long Non-Coding RNA in Cell and Tissue Homeostasis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Noncoding RNA (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/ncrna4010003"}], "href": "https://doi.org/10.3390/ncrna4010003"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29657300"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29657300"}]}]}]}