{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC00682 appears to play an important role in the epigenetic regulation of hepatocellular carcinoma (HCC). In one study, decreased methylation levels of LINC00682 were found to be significantly associated with tumor recurrence and reduced overall survival in HCC patients, and when combined with methylation markers of LINE‐2 and MAD1L1, the signature offered a synergistic prognostic value (1). Although additional details regarding its function are still emerging, the available evidence suggests that the methylation status of LINC00682 may serve as a promising biomarker for predicting HCC prognosis (1,2).\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n <small>\n (1)"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "; (2)"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "</small>\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Chenghua Cui, Zheming Lu, Liu Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genome-wide identification of differential methylation between primary and recurrent hepatocellular carcinomas."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Carcinog (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/mc.22359"}], "href": "https://doi.org/10.1002/mc.22359"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26138747"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26138747"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Xiaohong Zhang, Jian Li, Fan Li, et al. "}, {"type": "b", "children": [{"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "LINC00682"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " inhibits gastric cancer cell progression via targeting "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "microRNA-9"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": "-LMX1A signaling axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Aging (Albany NY) (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/aging.102533"}], "href": "https://doi.org/10.18632/aging.102533"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31822638"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31822638"}]}]}]}