{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC00683 is a long noncoding RNA that appears to play multifaceted roles in human cancer and possibly in mineral homeostasis. In prostate cancer, LINC00683 is significantly downregulated, and its reduced expression is strongly associated with decreased patient survival. Gene set enrichment analysis further implicates this lncRNA in cancer‐related pathways such as the Wnt signaling pathway, suggesting its potential value as both a diagnostic biomarker and a therapeutic target."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In bladder cancer, hypermethylation of the LINC00683 gene is observed in tumor tissues, and this epigenetic modification correlates with poorer overall survival. This finding underlines that DNA methylation–mediated suppression of LINC00683 may contribute to carcinogenesis and serve as a prognostic indicator."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Similarly, in cervical cancer, LINC00683 is incorporated into a prognostic signature along with specific mRNAs and miRNAs. Its inclusion in this model, which robustly predicts disease-free survival and recurrence, highlights its potential role in modulating tumor progression and recurrence risk."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Moreover, genetic association studies have identified a genomic region that includes LINC00683 as being linked to serum copper levels, suggesting that, beyond its implications in tumor biology, LINC00683 may also be involved in systemic processes such as mineral regulation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yunfeng Liu, Bishan Yang, Youmin Su, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Downregulation of long noncoding RNA LINC00683 associated with unfavorable prognosis in prostate cancer based on TCGA."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biochem (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcb.28691"}], "href": "https://doi.org/10.1002/jcb.28691"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30963639"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30963639"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Junhua Luo, Jinming Xu, Longhua Ou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Role of hypermethylated-lncRNAs in the prognosis of bladder cancer patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Int Med Res (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1177/03000605211049946"}], "href": "https://doi.org/10.1177/03000605211049946"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34617815"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34617815"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Mengxiong Li, Xiaohui Tian, Hongling Guo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A novel lncRNA-mRNA-miRNA signature predicts recurrence and disease-free survival in cervical cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Braz J Med Biol Res (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1590/1414-431X2021e11592"}], "href": "https://doi.org/10.1590/1414-431X2021e11592"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34550275"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34550275"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Duojian Guo, Yu Zhou, Xingwei Wei, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Preliminary study of genome-wide association identifies novel susceptibility genes for serum mineral elements in the Chinese Han population."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biol Trace Elem Res (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12011-021-02854-4"}], "href": "https://doi.org/10.1007/s12011-021-02854-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34417961"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34417961"}]}]}]}