{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC00687 is a long non‐coding RNA that has been implicated in multiple disease contexts through its dysregulated expression. In periodontitis, LINC00687 was identified as one of three hub differentially expressed lncRNAs via weighted gene co‐expression network analysis and differential expression analysis, suggesting that it may participate in a competing endogenous RNA network that modulates immune pathways—including neutrophil activation and antigen processing—that are critical for disease progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Furthermore, in an artificial intelligence–assisted genome-wide association study designed to predict heart failure progression, LINC00687 emerged as part of an SNP signature in asymptomatic high-risk individuals. This association hints at a potential regulatory role for LINC00687 in cardiac tissue remodeling and dysfunction, thereby offering a novel biomarker for early detection and risk stratification of heart failure."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Su-Han Jin, Rui-Hao Zhou, Xiao-Yan Guan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of novel key lncRNAs involved in periodontitis by weighted gene co-expression network analysis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Periodontal Res (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/jre.12693"}], "href": "https://doi.org/10.1111/jre.12693"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31512745"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31512745"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Ning-I Yang, Chi-Hsiao Yeh, Tsung-Hsien Tsai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Artificial Intelligence-Assisted Identification of Genetic Factors Predisposing High-Risk Individuals to Asymptomatic Heart Failure."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cells (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/cells10092430"}], "href": "https://doi.org/10.3390/cells10092430"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34572079"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34572079"}]}]}]}