{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC00691 is a long noncoding RNA with context‐dependent roles in tumorigenesis. In papillary thyroid cancer, curcumin treatment suppresses LINC00691 expression in B‑CPAP cells, which in turn promotes apoptosis, inhibits proliferation, and disrupts the Warburg effect via downregulation of Akt signaling."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In non‑small‑cell lung cancer, LINC00691 is significantly upregulated in tumor tissues, with high expression levels correlating with lymph node metastasis, advanced TNM stage, and poorer overall survival, thereby serving as an independent prognostic marker."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " In gastric cancer, elevated LINC00691 levels stimulate cell proliferation and invasion by activating Lin28 transcription and enhancing the Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway, which subsequently increases epidermal growth factor expression—a process that highlights its potential as a therapeutic target."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " In lung adenocarcinoma, although LINC00691 is among the most upregulated lncRNAs in tumor tissues relative to adjacent normal tissues, its specific functional implications remain to be fully defined."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " Conversely, in osteosarcoma, LINC00691 expression is reduced compared to control cells, and its overexpression inhibits proliferation, migration, and invasion while inducing G1 cell cycle arrest. Mechanistically, LINC00691 functions as a competing endogenous RNA by binding to miR-1256 to upregulate ST5 expression, thereby modulating epithelial-to-mesenchymal transition markers."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Zhihua Li, Youbing Gao, Lijun Li, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Overexpression of LINC00691 promotes the proliferation and invasion of gastric cancer cells via the Janus kinase/signal transducer and activator of transcription signalling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Biochem Cell Biol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.biocel.2020.105751"}], "href": "https://doi.org/10.1016/j.biocel.2020.105751"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32330554"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32330554"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Bing Zhao, Hang Xu, Xiaoye Ai, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "The lncRNA "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "LINC00691"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": "Functions as a ceRNA for "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "miRNA-1256"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " to Suppress Osteosarcoma by Regulating the Expression of "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "ST5"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": "."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Onco Targets Ther (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2147/OTT.S266435"}], "href": "https://doi.org/10.2147/OTT.S266435"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33380807"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33380807"}]}]}]}