{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC00702 is a long intergenic non‐protein coding RNA that exhibits context‐dependent roles in human diseases. In malignant meningioma, LINC00702 is upregulated and promotes cell proliferation and migration by acting as a molecular sponge for miR‑4652‑3p, thereby upregulating ZEB1 and activating the Wnt/β‑catenin signaling pathway."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In a contrasting cancer type, non‑small cell lung cancer, LINC00702 is downregulated, and forced expression of this lncRNA suppresses proliferation and metastasis via induction of apoptosis and modulation of PTEN expression by sponging miR‑510."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Similarly, in ovarian cancer, increased LINC00702 levels drive tumor progression: predominantly nuclear in localization, it interacts with EZH2 to inhibit the transcription of the tumor suppressor KLF2, thereby accelerating cell proliferation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " In colorectal cancer, LINC00702 is expressed at low levels and its overexpression restrains cell proliferation, migration, and invasion by promoting PTEN expression, leading to the repression of the PI3K/AKT pathway."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In other cancer types, LINC00702 has been identified within competing endogenous RNA (ceRNA) networks. In gastric cancer, for example, it forms part of a ceRNA framework associated with overall survival, underscoring its potential prognostic relevance."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " Moreover, its involvement in the pathogenesis of meningioma has also been highlighted in studies of pituitary tumors"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": ", and it appears among cancer‑related lncRNAs that independently correlate with prognosis in papillary renal cell carcinoma, suggesting its potential utility as a therapeutic target."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Beyond cancer, aberrant methylation of CpG sites within LINC00702 has been observed in non‑genital cutaneous warts, while its differential expression in endometrial cancer indicates promising specificity as a diagnostic biomarker."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": " Collectively, these findings reveal that LINC00702 can function either as an oncogene or as a tumor suppressor depending on the cellular context, emphasizing its potential as both a biomarker and a therapeutic target across a diverse spectrum of diseases.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Tengfei Li, Jianzhuang Ren, Ji Ma, et al. 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