{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC00703 is a long noncoding RNA that appears to play a tumor‐suppressive role in multiple cancers. In non‐small cell lung cancer (NSCLC), LINC00703 is significantly down‐regulated in tumor tissues and cell lines. Functional studies demonstrated that overexpression of LINC00703 in NSCLC cells inhibited proliferation, induced apoptosis, and triggered G1/G0 cell cycle arrest, concomitant with reduced expression of cyclinD1 and CDK4, suggesting that it suppresses NSCLC progression through the modulation of the cyclinD1/CDK4 axis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Similarly, in gastric cancer, LINC00703 is expressed at lower levels relative to normal tissues, and its overexpression not only restricts cell proliferation, migration, and invasion but also promotes apoptosis in vitro as well as tumor growth arrest in vivo. Mechanistically, LINC00703 functions as a competitive endogenous RNA by interacting with miR-181a, thereby relieving the miRNA-mediated suppression of Kruppel-like factor 6 (KLF6), a known tumor suppressor."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Collectively, these findings highlight LINC00703 as a potential diagnostic marker and therapeutic target in both NSCLC and gastric cancer through its regulation of key cell cycle and tumor suppressor pathways.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "H-B Sun, X-L Han, M Zhong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Linc00703 suppresses non-small cell lung cancer progression by modulating CyclinD1/CDK4 expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Rev Med Pharmacol Sci (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.26355/eurrev_202006_21508"}], "href": "https://doi.org/10.26355/eurrev_202006_21508"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32572878"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32572878"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Haiyang Yang, Minqi Peng, Yanjiao Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC00703 Acts as a Tumor Suppressor via Regulating miR-181a/KLF6 Axis in Gastric Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Gastric Cancer (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.5230/jgc.2019.19.e43"}], "href": "https://doi.org/10.5230/jgc.2019.19.e43"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31897348"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31897348"}]}]}]}