{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC00704, also known as MANCR, has emerged as an oncogenic long non‐coding RNA that is upregulated in several cancer types including breast cancer, lung adenocarcinoma, thyroid cancer, papillary thyroid carcinoma, and nasopharyngeal carcinoma. In breast cancer, LINC00704 appears within a recurrent signature, where its upregulation is associated with poorer prognosis, and depletion of its counterpart MANCR in triple‐negative breast cancer cells leads to decreased proliferation, viability, and increased DNA damage."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Similarly, in lung adenocarcinoma, elevated levels of MANCR promote cell proliferation, migration, and invasion while suppressing apoptosis, with knockdown experiments yielding significant inhibition of these malignant phenotypes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " In thyroid cancer, loss‐of‐function studies demonstrate that silencing LINC00704 impairs cell proliferation, colony formation, cell‐cycle progression, and invasion, further highlighting its role as a promoter of tumor aggressiveness."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " Mechanistic insights have been provided by studies in nasopharyngeal carcinoma and papillary thyroid carcinoma. In nasopharyngeal carcinoma, LINC00704 binds to the transcription factor ETS1 and promotes the transcription of cyclin‐dependent kinase 6 (CDK6), thereby driving cell cycle progression and enhancing proliferation as well as migration and invasion."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " In papillary thyroid carcinoma, LINC00704 functions as a competing endogenous RNA by sponging miR‐204‐5p, which results in upregulation of high‐mobility group box 1 (HMGB1) and consequently promotes cell proliferation, cell cycle progression, migration, and invasion."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these observations suggest that LINC00704 is a critical regulator of oncogenic pathways across diverse tumor types and holds promise as both a prognostic biomarker and a potential therapeutic target.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Hairong Liu, Juan Li, Pratirodh Koirala, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Mitotically-Associated lncRNA (MANCR) Affects Genomic Stability and Cell Division in Aggressive Breast Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Cancer Res (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/1541-7786.MCR-17-0548"}], "href": "https://doi.org/10.1158/1541-7786.MCR-17-0548"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29378907"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29378907"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Chang Liu, Haifeng Li, Xiaojing Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA MANCR positively affects the malignant progression of lung adenocarcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Pulm Med (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12890-021-01635-y"}], "href": "https://doi.org/10.1186/s12890-021-01635-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34418982"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34418982"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Wei Lu, Yongcan Xu, Jiewei Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of differential expressed lncRNAs in human thyroid cancer by a genome-wide analyses."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Med (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/cam4.1627"}], "href": "https://doi.org/10.1002/cam4.1627"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29923329"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29923329"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Yan Wang, Qi-Yan Tan, Ying Shen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC00704 contributes to the proliferation and accelerates the cell cycle of nasopharyngeal carcinoma cells via regulating ETS1/CDK6 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Kaohsiung J Med Sci (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/kjm2.12491"}], "href": "https://doi.org/10.1002/kjm2.12491"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34989116"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34989116"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Yihui Lin, Jianjia Jiang "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA LINC00704 promotes cell proliferation, migration, and invasion in papillary thyroid carcinoma via miR-204-5p/HMGB1 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Open Life Sci (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1515/biol-2020-0057"}], "href": "https://doi.org/10.1515/biol-2020-0057"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33817244"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33817244"}]}]}]}