{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC00705 is a long non‐coding RNA (lncRNA) identified in breast invasive carcinoma that appears to have prognostic significance. In a large TCGA breast cancer study, increased expression of LINC00705—along with several other lncRNAs—was found to be associated with tumor recurrence, suggesting that its upregulation may be indicative of a more aggressive disease course."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Although the precise cellular functions of LINC00705 were not directly characterized in this study, its inclusion as part of a recurrence‐predictive signature places it among lncRNAs with potential roles in oncogenic processes. This observation is consistent with broader transcriptomic analyses that have unveiled thousands of dysregulated lncRNAs in breast cancer, many of which contribute to critical aspects of tumor biology including cell proliferation, molecular subtype discrimination, and chemoresistance"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ";."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Furthermore, while other studies have explored lncRNAs in diverse contexts such as genetic regulation via cis‐regulatory modules (which may underlie differential gene expression patterns)"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "and even psychiatric disorders"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": ", the data support a model in which LINC00705, as part of the oncogenic lncRNA network, has potential utility as a prognostic biomarker and possibly as a component of regulatory pathways that drive breast cancer progression. \n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Hairong Liu, Juan Li, Pratirodh Koirala, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNAs as prognostic markers in human breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.7828"}], "href": "https://doi.org/10.18632/oncotarget.7828"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26942882"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26942882"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Andrew J Warburton, David N Boone "}, {"type": "b", "children": [{"type": "t", "text": "Insights from Global Analyses of Long Noncoding RNAs in Breast Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Curr Pathobiol Rep (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s40139-017-0122-1"}], "href": "https://doi.org/10.1007/s40139-017-0122-1"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28616363"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28616363"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Yudong Li, Baoxiao Wang, Hongna Lai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA CRALA is associated with poor response to chemotherapy in primary breast cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Thorac Cancer (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/1759-7714.12487"}], "href": "https://doi.org/10.1111/1759-7714.12487"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28834648"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28834648"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Joanna Mitchelmore, Nastasiya F Grinberg, Chris Wallace, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Functional effects of variation in transcription factor binding highlight long-range gene regulation by epromoters."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nucleic Acids Res (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/nar/gkaa123"}], "href": "https://doi.org/10.1093/nar/gkaa123"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32112106"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32112106"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "David M Howard, Lynsey S Hall, Jonathan D Hafferty, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genome-wide haplotype-based association analysis of major depressive disorder in Generation Scotland and UK Biobank."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Transl Psychiatry (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41398-017-0010-9"}], "href": "https://doi.org/10.1038/s41398-017-0010-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29187746"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29187746"}]}]}]}