{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Long intergenic non‐coding RNA LINC00707 has emerged as a multifunctional regulator in diverse biological processes, particularly in cancer progression and cellular differentiation. In multiple solid tumors—including gastric cancer"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ", lung adenocarcinoma"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ", colorectal cancer"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ", glioma"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ", breast"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": ", cervical"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": ", bladder"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": ", hepatocellular"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": ", and clear cell renal cell carcinoma"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": "—LINC00707 is frequently upregulated, with its overexpression correlating with advanced clinicopathological features and poorer prognosis. Mechanistically, LINC00707 acts primarily as a competing endogenous RNA (ceRNA) by “sponging” multiple microRNAs. For instance, in cancer cells it sequesters miR-370-3p"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": "and miR-145"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": "to modulate key targets such as WNT2B, LRP5, and downstream effectors of the Wnt/β-catenin pathway; it binds miR-206"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "12"}]}, {"type": "t", "text": "and miR-651-3p"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "13"}]}, {"type": "t", "text": "to enhance the expression of FMNL2 and SP2, and it regulates other miRNAs including miR-103a-3p"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "14"}]}, {"type": "t", "text": ", miR-382-5p"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": ", miR-223-5p"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "15"}]}, {"type": "t", "text": ", miR-330-5p"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "16"}]}, {"type": "t", "text": ", miR-338-3p"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "17"}]}, {"type": "t", "text": ", as well as miR-30a-5p"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "18"}]}, {"type": "t", "text": ", miR-490-3p"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "19"}]}, {"type": "t", "text": "and miR-199-3p."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "20"}]}, {"type": "t", "text": " This ceRNA activity releases the inhibition of various downstream effectors—including VAV3/F11R, Cdc42, CTHRC1, DKK1, VEGFA, CDCA3, AHSA1, FOXO1, ER-α, and Neurod1—thus modulating signaling pathways such as Wnt/β-catenin, ERK/JNK/AKT, and epithelial–mesenchymal transition. Beyond its oncogenic roles, LINC00707 also contributes to osteogenic differentiation of mesenchymal progenitors as evidenced by its ability to promote osteogenesis in bone marrow–derived mesenchymal stem cells."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}, {"type": "fg_f", "ref": "14"}, {"type": "fg_f", "ref": "19"}]}, {"type": "t", "text": " Furthermore, in non-neoplastic contexts such as pneumonia and osteoarthritis, LINC00707 is implicated in mediating inflammatory injury and apoptotic responses."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "15"}, {"type": "fg_f", "ref": "18"}, {"type": "fg_f", "ref": "20"}]}, {"type": "t", "text": " In addition, the inclusion of LINC00707 in prognostic signatures for melanoma"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "21"}]}, {"type": "t", "text": "and hypoxia-related models of lung adenocarcinoma"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "22"}]}, {"type": "t", "text": "underscores its potential as a robust biomarker. Overall, the multifaceted functions of LINC00707—as an oncogenic driver, a modulator of cellular differentiation, and a regulator of inflammatory responses—highlight its promise as a diagnostic biomarker and therapeutic target in a wide array of pathological settings."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "23"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Min Xie, Tianshi Ma, Jiangyang Xue, et al. 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