{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC00708 is a long intergenic non‐coding RNA located at the 10p14 locus that has recently been implicated in the modulation of human hair shape. Genome‐wide association analyses have identified a significant association between variation at this locus—often reported along with the adjacent transcription factor GATA3—and hair morphology, suggesting that genetic alterations in this region may influence hair follicle development and the resulting hair phenotype."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Although the abstract reporting this association focused on hair shape variation, other studies in the collection have addressed distinct traits such as colorectal cancer susceptibility"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "and other aspects of hair, including texture and face-related hair features"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ", without specifically elaborating on LINC00708’s role. Thus, while statistical association data implicate the 10p14 region harboring LINC00708 in the determination of hair shape, the precise biological function and regulatory mechanisms of LINC00708 remain to be elucidated.\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Overall, these findings indicate that LINC00708 could operate as part of a regulatory network that influences gene expression critical for hair follicle biology, thereby contributing to the phenotypic diversity of human hair. Future functional studies are needed to clarify whether LINC00708 exerts its effects directly or through modulation of neighboring genes such as GATA3.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Fan Liu, Yan Chen, Gu Zhu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Meta-analysis of genome-wide association studies identifies 8 novel loci involved in shape variation of human head hair."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Mol Genet (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/hmg/ddx416"}], "href": "https://doi.org/10.1093/hmg/ddx416"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29220522"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29220522"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Matthew P Salomon, Wai Lok Sibon Li, Christopher K Edlund, et al. "}, {"type": "b", "children": [{"type": "t", "text": "GWASeq: targeted re-sequencing follow up to GWAS."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Genomics (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12864-016-2459-y"}], "href": "https://doi.org/10.1186/s12864-016-2459-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26940994"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26940994"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Kaustubh Adhikari, Tania Fontanil, Santiago Cal, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A genome-wide association scan in admixed Latin Americans identifies loci influencing facial and scalp hair features."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/ncomms10815"}], "href": "https://doi.org/10.1038/ncomms10815"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26926045"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26926045"}]}]}]}