{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Long noncoding RNA LINC00709 appears to modulate susceptibility to colorectal neoplasia through its genetic variants. In one study examining familial risk of colorectal cancer (CRC), a single nucleotide polymorphism (SNP) within LINC00709 (rs11255841) was associated with an increased risk of CRC in first‐degree relatives of patients, suggesting that altered function or regulation of this lncRNA may contribute to cancer predisposition."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In contrast, a separate investigation that focused on colorectal adenomas reported that two SNPs within the LINC00709 gene (rs10795668 and rs11255841) were significantly associated with a reduced risk of low‐risk adenomas in both familial cases and controls. This finding implies a potential protective effect in the early stages of colorectal tumorigenesis, highlighting a complex role for LINC00709 where certain genetic variants may mitigate the progression from adenoma to carcinoma."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Although a third abstract detailing a targeted re‐sequencing approach in colon cancer did not specifically address LINC00709, this study exemplifies the broader strategy of using high‐throughput sequencing to identify both common and rare risk variants, including those in noncoding regions such as LINC00709, that can explain aspects of the “missing heritability” in CRC."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Carla J Gargallo-Puyuelo, Ángel Lanas, Patricia Carrera-Lasfuentes, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Familial Colorectal Cancer and Genetic Susceptibility: Colorectal Risk Variants in First-Degree Relatives of Patients With Colorectal Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Clin Transl Gastroenterol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.14309/ctg.0000000000000301"}], "href": "https://doi.org/10.14309/ctg.0000000000000301"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33534415"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33534415"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Carla J Gargallo, Ángel Lanas, Patricia Carrera-Lasfuentes, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genetic susceptibility in the development of colorectal adenomas according to family history of colorectal cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Cancer (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/ijc.31858"}], "href": "https://doi.org/10.1002/ijc.31858"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30194776"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30194776"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Matthew P Salomon, Wai Lok Sibon Li, Christopher K Edlund, et al. "}, {"type": "b", "children": [{"type": "t", "text": "GWASeq: targeted re-sequencing follow up to GWAS."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Genomics (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12864-016-2459-y"}], "href": "https://doi.org/10.1186/s12864-016-2459-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26940994"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26940994"}]}]}]}