{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Long non‐coding RNA LINC00710 appears to be involved in tissue‐specific regulatory processes. In lung adenocarcinoma, LINC00710 is among the most significantly downregulated lncRNAs when compared to adjacent non-tumorous tissue; however, its decreased expression does not show a significant association with clinicopathologic parameters such as age, gender, tumor stage, or metastasis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In addition, analyses of human germ cell populations have identified LINC00710 as one of a set of lncRNAs exhibiting consistent differential expression, suggesting a possible role in spermatogenesis or germ cell development, although the precise biological targets and mechanisms remain to be elucidated."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Notably, while other lncRNAs like LINC00668 have been characterized with oncogenic functions in hepatocellular carcinoma"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ", no direct functional role has yet been attributed to LINC00710 in this context. Overall, the distinct expression patterns of LINC00710 in lung adenocarcinoma and germ cells highlight its potential importance in cellular regulatory networks and underscore the need for further studies to determine its mechanistic contributions.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Bing Zhao, Hang Xu, Xiaoye Ai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression profiles of long noncoding RNAs in lung adenocarcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Onco Targets Ther (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2147/OTT.S167633"}], "href": "https://doi.org/10.2147/OTT.S167633"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30233202"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30233202"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Meghali Joshi, Singh Rajender "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNAs (lncRNAs) in spermatogenesis and male infertility."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Reprod Biol Endocrinol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12958-020-00660-6"}], "href": "https://doi.org/10.1186/s12958-020-00660-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33126901"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33126901"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Xiangkun Wang, Xin Zhou, Junqi Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genome‑wide investigation of the clinical implications and molecular mechanism of long noncoding RNA LINC00668 and protein‑coding genes in hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Oncol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/ijo.2019.4858"}], "href": "https://doi.org/10.3892/ijo.2019.4858"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31432149"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31432149"}]}]}]}