{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC00824, a long intergenic non‑protein coding RNA, appears to play diverse roles in human disease. In hepatocellular carcinoma, for example, high‐throughput sequencing identified integration of hepatitis B virus DNA into genomic regions including LINC00824, suggesting that such viral insertions may contribute to tumorigenesis through dysregulation of local gene expression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In chronic obstructive pulmonary disease, specific polymorphisms in LINC00824 (rs7815944) were found to confer protective effects against disease development, implicating LINC00824 in modulating susceptibility to pulmonary inflammation and structural changes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Moreover, genome‑wide association studies in primary spontaneous pneumothorax have reported that an intergenic SNP between LINC00824 and a neighboring lncRNA is associated with increased disease risk, indicating that genetic variability in this region may influence lung tissue integrity."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Complementary insights come from transcriptomic analyses in smokers, where differential expression of LINC00824 was observed in whole blood, suggesting that environmental exposures such as cigarette smoke may modulate its expression and, consequently, related regulatory networks."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " Finally, in inflammatory bowel disease, genetic association studies have identified a risk allele (rs6651252) within LINC00824 that correlates with an increased risk of Crohn’s disease, highlighting its potential role as a genetic modifier in inflammatory pathways."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Together, these findings indicate that LINC00824 functions as a regulatory noncoding RNA whose alteration—whether by viral integration, single nucleotide polymorphisms, or environmental modulation—may contribute to the pathogenesis of diverse conditions including cancer, pulmonary, and inflammatory diseases. Further functional studies are warranted to elucidate the molecular mechanisms underpinning its role.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Zebao He, Jiansheng Zhu, Jinggang Mo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "HBV DNA integrates into upregulated ZBTB20 in patients with hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Med Rep (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/mmr.2020.11074"}], "href": "https://doi.org/10.3892/mmr.2020.11074"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32319639"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32319639"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Xiaoman Zhou, Yunjun Zhang, Yutian Zhang, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "RNA sequencing identifies novel non-coding RNA and exon-specific effects associated with cigarette smoking."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Med Genomics (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12920-017-0295-9"}], "href": "https://doi.org/10.1186/s12920-017-0295-9"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28985737"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28985737"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Laurence Don Wai Luu, Georgia Popple, Samuel Pok Wei Tsang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genetic variants involved in innate immunity modulate the risk of inflammatory bowel diseases in an understudied Malaysian population."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Gastroenterol Hepatol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/jgh.15752"}], "href": "https://doi.org/10.1111/jgh.15752"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34888949"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34888949"}]}]}]}