{"type": "root", "children": [{"type": "t", "text": "<head>\n <meta charset=\"UTF-8\">\n <title>Summary of LINC00836 Function</title>\n </head>\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Recent studies have begun to elucidate the regulatory functions of the long noncoding RNA LINC00836 in neurological disease contexts. In the setting of Alzheimer’s disease, LINC00836 has been identified as a key component within an immune-related competing endogenous RNA network. Specifically, when microRNA inhibition occurs, LINC00836 appears to modulate several immune hub genes—such as B2M, FYN, PIK3R1, and PIK3CA—that are implicated in AD pathogenesis, suggesting that it may contribute to the regulation of immune responses in the disease."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In contrast, a separate investigation aimed at defining a gene signature for glioblastoma identified a set of 33 differentially expressed genes; however, LINC00836 was not specifically highlighted within this glioblastoma signature."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Together, these findings point to a potential role for LINC00836 as a regulatory lncRNA in immune-related phenomena in Alzheimer’s disease, while its involvement in glioblastoma remains to be determined.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Hui Xu, Jianping Jia "}, {"type": "b", "children": [{"type": "t", "text": "Immune-Related Hub Genes and the Competitive Endogenous RNA Network in Alzheimer's Disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Alzheimers Dis (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3233/JAD-200081"}], "href": "https://doi.org/10.3233/JAD-200081"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32925027"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32925027"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Chih-Hao Lu, Sung-Tai Wei, Jia-Jun Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Recognition of a Novel Gene Signature for Human Glioblastoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Sci (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/ijms23084157"}], "href": "https://doi.org/10.3390/ijms23084157"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35456975"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35456975"}]}]}]}