{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC00837 is a long intergenic non‐coding RNA that has been implicated in diverse biological contexts. In osteosarcoma, LINC00837 was identified as one of six lncRNAs whose combined expression signature showed a strong association with patient prognosis, tumor purity, and metastatic potential, suggesting that it may serve as a predictive biomarker and contribute to tumor progression and microenvironment modulation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In a separate study focusing on the immediate cellular responses to altered gravitational forces, LINC00837 was among a few gravity‐regulated genes in human T lymphocytic cells that responded rapidly (within seconds to minutes) to changes in gravitational environments, implying a role in the quick adaptation of cellular function under physical stress."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Although investigations in human testes and brain have primarily focused on the roles of other regulatory RNAs such as piRNAs in mediating genomic stability and disease processes"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ", the identification of LINC00837 in both osteosarcoma and gravity-stress experiments highlights its emerging importance as a regulatory non-coding RNA, potentially intersecting with broader RNA-mediated networks that govern gene expression in response to pathological and environmental cues.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yi He, Haiting Zhou, Haoran Xu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Construction of an Immune-Related lncRNA Signature That Predicts Prognosis and Immune Microenvironment in Osteosarcoma Patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Oncol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fonc.2022.769202"}], "href": "https://doi.org/10.3389/fonc.2022.769202"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35494024"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35494024"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Cora S Thiel, Swantje Hauschild, Andreas Huge, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Dynamic gene expression response to altered gravity in human T cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-017-05580-x"}], "href": "https://doi.org/10.1038/s41598-017-05580-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28701719"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28701719"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Hongseok Ha, Jimin Song, Shuoguo Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A comprehensive analysis of piRNAs from adult human testis and their relationship with genes and mobile elements."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Genomics (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/1471-2164-15-545"}], "href": "https://doi.org/10.1186/1471-2164-15-545"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24981367"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24981367"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Wenying Qiu, Xiaoyun Guo, Xiandong Lin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Transcriptome-wide piRNA profiling in human brains of Alzheimer's disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neurobiol Aging (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.neurobiolaging.2017.05.020"}], "href": "https://doi.org/10.1016/j.neurobiolaging.2017.05.020"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28654860"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28654860"}]}]}]}