{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC00839 is an emerging long noncoding RNA that has been found to play multifaceted, predominantly oncogenic roles in a range of disorders. In hepatocellular carcinoma, LINC00839 is upregulated and functions as a competing endogenous RNA (ceRNA) by sponging miR‑144‑3p, which in turn leads to enhanced expression of WTAP and promotes cell proliferation, migration, invasion, and resistance to apoptosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In acute myeloid leukemia, its expression is incorporated into prognostic models, indicating its potential as a risk marker"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ", while dysregulated levels have also been noted in the context of childhood obesity, where it is identified as a key RNA in ceRNA networks, although its mechanistic role remains to be fully elucidated."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In lung cancer, overexpression of LINC00839 contributes to tumor progression by sponging miR‑519d‑3p, thereby upregulating JMJD6 and enhancing cell viability, invasion, and migration with concomitant inhibition of apoptosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " Similarly, in acute lung injury models, LINC00839 is negatively regulated by sevoflurane; its overexpression normally promotes inflammation and pyroptosis through the miR‑223/NLRP3 axis, suggesting that its downregulation is protective."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In neuroblastoma, elevated LINC00839 levels correlate with poor survival outcomes; mechanistic studies indicate that it enhances glycolysis, proliferation, migration, and invasion by modulating the miR‑338‑3p/GLUT1 axis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " Its prognostic relevance is further underscored by its incorporation into lncRNA signatures in other cancer types such as nasopharyngeal carcinoma, where deletion of LINC00839 suppresses rapid growth, invasive capacity, and epithelial–mesenchymal transition."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n In breast cancer, LINC00839 is upregulated in chemoresistant cells and tissues, with its transcription activated by Myc. It contributes to enhanced proliferation, invasion, migration, and paclitaxel resistance by interacting with Lin28B and activating the PI3K/AKT signaling pathway, thereby forming a positive feedback loop with Myc."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": " Moreover, in the context of viral oncogenesis, LINC00839 is among a subset of host long noncoding RNAs bound by the Kaposi’s sarcoma‐associated herpesvirus ORF57 protein, implicating it in cell growth regulation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "9"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these studies highlight that LINC00839 acts as a pivotal regulatory hub—predominantly through its role as a miRNA sponge—that modulates downstream effectors involved in cell proliferation, migration, invasion, apoptosis, and inflammatory responses across diverse pathologies. Its dysregulation suggests potential utility as both a prognostic biomarker and a therapeutic target in various diseases.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Xingqin Zhou, Yazhou Chang, Lirong Zhu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC00839/miR-144-3p/WTAP (WT1 Associated protein) axis is involved in regulating hepatocellular carcinoma progression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bioengineered (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/21655979.2021.1990578"}], "href": "https://doi.org/10.1080/21655979.2021.1990578"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34634995"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34634995"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Chao Guo, Qian-Qian Ju, Chun-Xia Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Overexpression of HOXA10 is associated with unfavorable prognosis of acute myeloid leukemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Cancer (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12885-020-07088-6"}], "href": "https://doi.org/10.1186/s12885-020-07088-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32571260"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32571260"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Rui Chen, Guangda Xin, Xiaofei Zhang "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA HCP5 serves as a ceRNA sponging miR-17-5p and miR-27a/b to regulate the pathogenesis of childhood obesity via the MAPK signaling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Pediatr Endocrinol Metab (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1515/jpem-2018-0432"}], "href": "https://doi.org/10.1515/jpem-2018-0432"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31622249"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31622249"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Xiaoyan Yu, Yifei Jiang, Xun Hu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC00839/miR-519d-3p/JMJD6 axis modulated cell viability, apoptosis, migration and invasiveness of lung cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Folia Histochem Cytobiol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.5603/FHC.a2021.0022"}], "href": "https://doi.org/10.5603/FHC.a2021.0022"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34734406"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34734406"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Zhiling Fu, Xiuying Wu, Fushuang Zheng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Sevoflurane anesthesia ameliorates LPS-induced acute lung injury (ALI) by modulating a novel LncRNA LINC00839/miR-223/NLRP3 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Pulm Med (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12890-022-01957-5"}], "href": "https://doi.org/10.1186/s12890-022-01957-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35473680"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35473680"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Lixia Yang, Liangyan Pei, Jilong Yi "}, {"type": "b", "children": [{"type": "t", "text": "LINC00839 Regulates Proliferation, Migration, Invasion, Apoptosis and Glycolysis in Neuroblastoma Cells Through miR-338-3p/GLUT1 Axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Neuropsychiatr Dis Treat (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2147/NDT.S309467"}], "href": "https://doi.org/10.2147/NDT.S309467"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34188473"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34188473"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Feng Ying Zhang, Xia Li, Ting Ting Huang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC00839 knockdown restrains the metastatic behavior of nasopharyngeal carcinoma by sponging miR-454-3p."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Aging (Albany NY) (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/aging.203792"}], "href": "https://doi.org/10.18632/aging.203792"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34965215"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34965215"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Qi Chen, Huiling Shen, Xiaolan Zhu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A nuclear lncRNA Linc00839 as a Myc target to promote breast cancer chemoresistance via PI3K/AKT signaling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Sci (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/cas.14555"}], "href": "https://doi.org/10.1111/cas.14555"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32619088"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32619088"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Beatriz Alvarado-Hernandez, Yanping Ma, Nishi R Sharma, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Protein-RNA Interactome Analysis Reveals Wide Association of Kaposi's Sarcoma-Associated Herpesvirus ORF57 with Host Noncoding RNAs and Polysomes."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Virol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1128/JVI.01782-21"}], "href": "https://doi.org/10.1128/JVI.01782-21"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34787459"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34787459"}]}]}]}