{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Recent studies have suggested that LINC00840, a long non‐coding RNA, may play an important role in both cancer prognosis and epigenetic regulation. In one investigation, an improved survival analysis method that integrated gene interaction information into a Reweighted Random Survival Forest (RRSF) model identified a prognostic signature composed of two coding genes and three lncRNAs – among which LINC00840 was included – in patients with glioblastoma multiforme and esophageal squamous cell carcinoma. This finding implies that LINC00840 might influence tumor progression and patient survival through its participation in mRNA–lncRNA co‐expression networks that are biologically relevant to tumor development."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In a separate study focused on epigenome‐wide associations, differential DNA methylation patterns were examined in relation to early-life nutritional exposures such as breastfeeding. Although the report was truncated regarding the specific differentially methylated positions, the overall findings raise the possibility that LINC00840 could be subject to epigenetic modifications that may alter its expression profile over time in response to environmental factors. Such epigenetic regulation further supports the notion that LINC00840 may have long-term implications for gene expression and disease susceptibility."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Wei Wang, Wei Liu "}, {"type": "b", "children": [{"type": "t", "text": "Integration of gene interaction information into a reweighted random survival forest approach for accurate survival prediction and survival biomarker discovery."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-018-31497-0"}], "href": "https://doi.org/10.1038/s41598-018-31497-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30181543"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30181543"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "William B Sherwood, Dilini M Kothalawala, Latha Kadalayil, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Epigenome-Wide Association Study Reveals Duration of Breastfeeding Is Associated with Epigenetic Differences in Children."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Environ Res Public Health (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/ijerph17103569"}], "href": "https://doi.org/10.3390/ijerph17103569"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32443666"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32443666"}]}]}]}