{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\nLong noncoding RNAs are increasingly recognized as pivotal regulators of cancer biology, acting through diverse mechanisms. For instance, one study identified ELIT-1—a TGFβ-induced lncRNA that binds Smad3 to reinforce TGFβ/Smad signaling and promote epithelial-mesenchymal transition (EMT) in lung adenocarcinoma and gastric cancer."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nIn pancreatic ductal adenocarcinoma (PDAC), LINC00842 is markedly upregulated in response to high glucose conditions via the transcription factor YY1. This long intergenic noncoding RNA binds specifically to acetylated PGC-1α and prevents its deacetylation by SIRT1. Consequently, the sustained acetylated state of PGC-1α shifts cellular metabolism from mitochondrial oxidative catabolism toward fatty acid synthesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "t", "text": "\n\n"}, {"type": "p", "children": [{"type": "t", "text": "\nThe metabolic reprogramming driven by LINC00842 enhances malignant phenotypes by promoting PDAC cell growth and invasiveness, which correlates with poor patient survival. Thus, while other lncRNAs such as ELIT-1 modulate key signaling pathways like TGFβ/Smad3 to drive tumor progression, LINC00842 acts primarily through rewiring metabolic pathways, emerging as a promising therapeutic target in PDAC."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n"}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Satoshi Sakai, Tatsuya Ohhata, Kyoko Kitagawa, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long Noncoding RNA "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "ELIT-1"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " Acts as a Smad3 Cofactor to Facilitate TGFβ/Smad Signaling and Promote Epithelial-Mesenchymal Transition."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Res (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1158/0008-5472.CAN-18-3210"}], "href": "https://doi.org/10.1158/0008-5472.CAN-18-3210"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30952633"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30952633"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Xudong Huang, Ling Pan, Zhixiang Zuo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC00842 inactivates transcription co-regulator PGC-1α to promote pancreatic cancer malignancy through metabolic remodelling."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Nat Commun (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41467-021-23904-4"}], "href": "https://doi.org/10.1038/s41467-021-23904-4"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34158490"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34158490"}]}]}]}