{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC00843 has emerged as a potential biomarker and regulator in cancer progression. In gastric cancer, LINC00843 was identified as one of four key long noncoding RNAs in a prognostic risk score model that discriminated between patients with high and low recurrence risk. Through its inclusion in a competing endogenous RNA network, LINC00843 may influence the Wnt-signaling pathway by modulating microRNAs and associated mRNAs, thereby potentially contributing to metastasis and tumor recurrence."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In neuroblastoma, LINC00843 was among the lncRNAs found to interact with EZH2, a chromatin modifier implicated in tumorigenesis, suggesting that its binding with EZH2 might play a role in the complex regulatory mechanisms driving cancer development."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Qiang Chen, Zunqi Hu, Xin Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A four-lncRNA signature for predicting prognosis of recurrence patients with gastric cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Open Med (Wars) (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1515/med-2021-0241"}], "href": "https://doi.org/10.1515/med-2021-0241"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33869776"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33869776"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Mujie Ye, Lulu Xie, Jingjing Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Determination of long non-coding RNAs associated with EZH2 in neuroblastoma by RIP-seq, RNA-seq and ChIP-seq."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Lett (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/ol.2020.11862"}], "href": "https://doi.org/10.3892/ol.2020.11862"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32774475"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32774475"}]}]}]}