{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC00844 is emerging as a key long noncoding RNA involved in the regulation of cellular processes in several disease contexts. In prostate cancer, LINC00844 is downregulated, and its overexpression suppresses tumor progression by recruiting the transcription factor EBF1 to upregulate GSTP1, which in turn reduces cell proliferation and enhances apoptosis (a tumor‐suppressive effect)."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In hepatocellular carcinoma, independent studies have similarly demonstrated that low LINC00844 expression correlates with aggressive tumor characteristics, whereas its restoration inhibits cell proliferation, migration, and invasion, partly through the downregulation of oncogenic targets such as NDRG1."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Moreover, in the context of liver toxicity, LINC00844 is highly enriched in the liver and plays a regulatory role in drug metabolism by modulating key drug‐metabolizing enzymes and nuclear receptors; it acts, at least in part, as a sponge for hsa‐miR-486-5p to protect targets like SULT2A1, thereby influencing acetaminophen-induced toxicity."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " Beyond its function in liver and liver-derived cancers, LINC00844 has been integrated into several prognostic and ceRNA signatures in glioma (including ferroptosis-related and enhancer RNA profiles) and in recurrent implantation failure, indicating its potential as a biomarker."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "5", "end_ref": "7"}]}, {"type": "t", "text": " Additionally, in atrial fibrillation, LINC00844 expression is inversely correlated with the abundance of resting dendritic cells, suggesting a possible role in modulating immune cell infiltration and the atrial inflammatory milieu."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Kaiyan Qiu, Zhixiong Zheng, Yingfu Huang "}, {"type": "b", "children": [{"type": "t", "text": "Long intergenic noncoding RNA 00844 promotes apoptosis and represses proliferation of prostate cancer cells through upregulating GSTP1 by recruiting EBF1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Physiol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcp.29690"}], "href": "https://doi.org/10.1002/jcp.29690"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32329523"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32329523"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Wei Zhou, Kang Huang, Qiuyan Zhang, et al. 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