{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC00847 has emerged as a multifunctional long non‐coding RNA that is dysregulated in several human diseases. In laryngeal squamous cell carcinoma, for instance, LINC00847 is overexpressed in tumor tissues and predominantly localized in the cytoplasm, where it enhances cell proliferation, migration, invasion, and cell cycle progression. Mechanistically, it acts as a competing endogenous RNA to sequester microRNA‐181a‐5p, leading to increased expression of pro‐tumorigenic mediators such as ZEB2."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In the context of inflammatory diseases, increased levels of LINC00847 in peripheral blood mononuclear cells have been associated with asthma exacerbation in children, suggesting that it may serve as a potential biomarker for discriminating between exacerbation and remission states."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Moreover, bioinformatics analysis in renal cell carcinoma models has indicated that modulation of LINC00847—as observed in studies involving bacterial toxin (the Staphylococcus aureus tst gene)—may be linked to the regulation of apoptotic pathways."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Its identification within competing endogenous RNA networks in primary Sjögren’s syndrome also points to a possible contributory role in immune cell dysregulation."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " Furthermore, exposure to the hepatotoxin microcystin‐LR provokes upregulation of LINC00847 alongside other lncRNAs, with pathway enrichment analyses implicating it in signaling cascades such as PI3K–AKT and MAPK that may underlie liver damage."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these findings highlight the multifaceted roles of LINC00847 in promoting malignant behaviors in cancer, modulating inflammatory responses, and contributing to toxin‐induced tissue injury. Further research into its molecular mechanisms may provide insights into its potential as both a biomarker and a therapeutic target across diverse disease settings.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Wei Li, Xionghui Hu, Xiaolin Huang "}, {"type": "b", "children": [{"type": "t", "text": "Long intergenic non-protein coding RNA 847 promotes laryngeal squamous cell carcinoma progression through the microRNA-181a-5p/zinc finger E-box binding homeobox 2 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bioengineered (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/21655979.2022.2062531"}], "href": "https://doi.org/10.1080/21655979.2022.2062531"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35435130"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35435130"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Jiaying Hu, Zhike Wang, Suzhen Han, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Expression of LINC00847 in Peripheral Blood Mononuclear Cells of Children with Asthma and Its Prediction between Asthma Exacerbation and Remission."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Genet Res (Camb) (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2022/5678257"}], "href": "https://doi.org/10.1155/2022/5678257"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35356750"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35356750"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Maryam Safarpour-Dehkordi, Abbas Doosti, Mohammad-Saied Jami "}, {"type": "b", "children": [{"type": "t", "text": "Integrative Analysis of lncRNAs in Kidney Cancer to Discover A New lncRNA ("}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "LINC00847"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": ") as A Therapeutic Target for Staphylococcal Enterotoxin "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "tst"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " Gene."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell J (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.22074/cellj.2020.6996"}], "href": "https://doi.org/10.22074/cellj.2020.6996"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32779439"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32779439"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Xiaochan Chen, Qi Cheng, Yan Du, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Differential long non-coding RNA expression profile and function analysis in primary Sjogren's syndrome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Immunol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12865-021-00439-3"}], "href": "https://doi.org/10.1186/s12865-021-00439-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34284720"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34284720"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Cong Wen, Shu Yang, Shuilin Zheng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Analysis of long non-coding RNA profiled following MC-LR-induced hepatotoxicity using high-throughput sequencing."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Toxicol Environ Health A (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/15287394.2018.1532717"}], "href": "https://doi.org/10.1080/15287394.2018.1532717"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30430930"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30430930"}]}]}]}