{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Long non‐coding RNAs (lncRNAs) have emerged as powerful regulators in diverse biological contexts—ranging from muscle development and homeostasis to the pathology of muscular dystrophies and certain cancers."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "4"}]}, {"type": "t", "text": "\n Although the abstracts provided discuss several lncRNAs that influence gene expression, muscle differentiation, splicing regulation, and even cancer prognosis"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": ", none of them specifically address the function or biological role of LINC00850.\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n By extrapolating from the general functions shared by lncRNAs in these studies, one may hypothesize that LINC00850 could similarly participate in the fine‐tuning of gene regulatory networks. In muscle biology, for example, lncRNAs are known to orchestrate developmental programs, maintain cell identity, and modulate the splicing of transcripts involved in muscle integrity. In disease settings—ranging from muscular dystrophies to oncogenesis—these transcripts can serve as biomarkers or even therapeutic targets. Thus, if LINC00850 follows similar functional paradigms, it may be involved in regulating transcriptional programs critical to muscle development and/or in modulating pathological processes in diseases. However, the precise molecular functions and potential clinical implications of LINC00850 remain to be elucidated in future dedicated studies.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Maria Victoria Neguembor, Mathivanan Jothi, Davide Gabellini "}, {"type": "b", "children": [{"type": "t", "text": "Long noncoding RNAs, emerging players in muscle differentiation and disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Skelet Muscle (2014)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/2044-5040-4-8"}], "href": "https://doi.org/10.1186/2044-5040-4-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24685002"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24685002"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Daniela Erriquez, Giovanni Perini, Alessandra Ferlini "}, {"type": "b", "children": [{"type": "t", "text": "Non-coding RNAs in muscle dystrophies."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Sci (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/ijms141019681"}], "href": "https://doi.org/10.3390/ijms141019681"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "24084719"}], "href": "https://pubmed.ncbi.nlm.nih.gov/24084719"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Mao Nie, Zhong-Liang Deng, Jianming Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Noncoding RNAs, Emerging Regulators of Skeletal Muscle Development and Diseases."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biomed Res Int (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2015/676575"}], "href": "https://doi.org/10.1155/2015/676575"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26258142"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26258142"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Thi Hoai Thu Tran, Zhujun Zhang, Mariko Yagi, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Molecular characterization of an X(p21.2;q28) chromosomal inversion in a Duchenne muscular dystrophy patient with mental retardation reveals a novel long non-coding gene on Xq28."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Hum Genet (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/jhg.2012.131"}], "href": "https://doi.org/10.1038/jhg.2012.131"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23223008"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23223008"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Xianfeng Ding, Yuhan Zhang, Hongjian Yang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNAs may serve as biomarkers in breast cancer combined with primary lung cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.17356"}], "href": "https://doi.org/10.18632/oncotarget.17356"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28938549"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28938549"}]}]}]}