{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n A recent genome‐wide association study conducted in a cohort of Hispanic boys with biopsy‐proven nonalcoholic fatty liver disease (NAFLD) identified several novel genetic variants that are associated with both obesity and insulin resistance, two key features underlying the metabolic syndrome (1). Although the study primarily highlighted associations with coding genes such as CAMK1D and several variants on chromosome 2, one of the implicated regions involves a long intergenic noncoding RNA, LINC00851. While the specific mechanistic role of LINC00851 was not fully delineated in this investigation, its location among the novel genomic variants suggests that LINC00851 may be involved in the regulatory control of pathways that modulate adiposity and insulin sensitivity. The presence of significant correlations between genetic variation in this region and metabolic traits supports the notion that LINC00851 could play a role in the molecular pathogenesis of NAFLD through regulation of metabolic homeostasis (1)."}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "John C Rausch, Joel E Lavine, Naga Chalasani, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genetic Variants Associated With Obesity and Insulin Resistance in Hispanic Boys With Nonalcoholic Fatty Liver Disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Pediatr Gastroenterol Nutr (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1097/MPG.0000000000001926"}], "href": "https://doi.org/10.1097/MPG.0000000000001926"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29470286"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29470286"}]}]}]}