{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC00852 is emerging as an oncogenic long non‐coding RNA whose aberrant expression contributes to multiple aspects of tumor progression across diverse cancer types. In osteosarcoma, LINC00852 is highly enriched in AXL‐associated exosomes and functions, at least in part, to enhance AXL expression by competitively binding to miR‐7‑5p, thereby establishing a positive feedback loop that promotes cell proliferation, migration, and invasion."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In ovarian cancer, up‐regulation of LINC00852 acts as a competing endogenous RNA (ceRNA) for miR‐140‑3p, which leads to increased AGTR1 expression and subsequent activation of the MEK/ERK/STAT3 signaling pathway; consequently, its knockdown suppresses cellular viability, proliferation, and invasion while inducing apoptosis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " In gastric cancer, exosomal LINC00852 derived from cisplatin‐resistant cells contributes to drug resistance by sequestering miR‑514a‑5p and thus relieving its repression of COMMD7, which facilitates resistance to cisplatin treatment."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Furthermore, in prostate cancer, overexpression of LINC00852 accelerates cellular proliferation and enhances metastatic potential, in part through modulation of epithelial–mesenchymal transition and cell cycle progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " In hepatocellular carcinoma, LINC00852 promotes tumor cell proliferation, migration, and invasion while inhibiting apoptosis by sponging miR‑625 to upregulate E2F1 expression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " Similarly, in non‑small cell lung cancer, elevated LINC00852 levels correlate with poor overall survival and chemoresistance; mechanistically, it modulates the hsa‑miR‑145‑5p/KLF4 axis to influence cell proliferation, cisplatin sensitivity, and cell cycle progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": " Finally, in colon adenocarcinoma, LINC00852 has been identified as one of several prognostic lncRNA signatures associated with tumor recurrence, underscoring its potential value as a biomarker for disease progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Qiming Li, Xuedi Wang, Nian Jiang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Exosome-transmitted linc00852 associated with receptor tyrosine kinase AXL dysregulates the proliferation and invasion of osteosarcoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Med (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/cam4.3303"}], "href": "https://doi.org/10.1002/cam4.3303"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32673448"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32673448"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Zhi-Wei Qiao, Ying Jiang, Ling Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC00852 promotes the proliferation and invasion of ovarian cancer cells by competitively binding with miR-140-3p to regulate AGTR1 expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Cancer (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12885-021-08730-7"}], "href": "https://doi.org/10.1186/s12885-021-08730-7"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34496800"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34496800"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Shuguang Cao, Beilei Fu, Jing Cai, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Linc00852 from cisplatin-resistant gastric cancer cell-derived exosomes regulates COMMD7 to promote cisplatin resistance of recipient cells through microRNA-514a-5p."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Biol Toxicol (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s10565-021-09685-y"}], "href": "https://doi.org/10.1007/s10565-021-09685-y"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35088190"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35088190"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Shengming Yi, Guiyuan Li, Biaofeng Sun "}, {"type": "b", "children": [{"type": "t", "text": "Overexpression of LINC00852 promotes prostate cancer cell proliferation and metastasis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Asia Pac J Clin Oncol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/ajco.13418"}], "href": "https://doi.org/10.1111/ajco.13418"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33128330"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33128330"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Shi Chen "}, {"type": "b", "children": [{"type": "t", "text": "LINC00852 Regulates Cell Proliferation, Invasion, Migration and Apoptosis in Hepatocellular Carcinoma "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "Via"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " the miR-625/E2F1 Axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Mol Bioeng (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12195-021-00714-8"}], "href": "https://doi.org/10.1007/s12195-021-00714-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35401844"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35401844"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Zineng Tuo, Li Liang, Rongmei Zhou "}, {"type": "b", "children": [{"type": "t", "text": "LINC00852 is associated with poor prognosis in non-small cell lung cancer patients and its inhibition suppresses cancer cell proliferation and chemoresistance via the hsa-miR-145-5p/KLF4 axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Gene Med (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jgm.3384"}], "href": "https://doi.org/10.1002/jgm.3384"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34342374"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34342374"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Lipeng Jin, Chenyao Li, Tao Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A potential prognostic prediction model of colon adenocarcinoma with recurrence based on prognostic lncRNA signatures."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Hum Genomics (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s40246-020-00270-8"}], "href": "https://doi.org/10.1186/s40246-020-00270-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32522293"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32522293"}]}]}]}