{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Recent studies have begun to delineate a context‐dependent role for the long noncoding RNA LINC00853 in cancer. In hepatocellular carcinoma (HCC), LINC00853 was identified among several upregulated lncRNAs and—uniquely when measured in small extracellular vesicles—displayed a marked increase in patient samples. Notably, extracellular vesicle–derived LINC00853 exhibited excellent diagnostic performance for all-stage HCC, suggesting it may serve as a promising noninvasive biomarker in this malignancy."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In contrast, in T cell acute lymphoblastic leukemia (T-ALL), LINC00853 was found to be downregulated and inversely correlated with the expression of the chemokine receptor CCR9. Functional studies in T-ALL cell lines revealed that LINC00853 suppresses cell migration and invasion, thereby restraining leukemic infiltration into multiple organs. This evidence positions LINC00853 as a potential tumor suppressor in the context of leukemic dissemination."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In addition, broader investigations into lncRNA biology have highlighted diverse mechanisms—such as enhancer-like activity, chromosomal looping, and RNA-mediated recruitment of protein effectors—in regulating gene expression and cellular differentiation."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "3", "end_ref": "6"}]}, {"type": "t", "text": " Although these studies do not address LINC00853 directly, they underscore the potential for lncRNAs—including LINC00853—to engage in regulatory activities in a tissue-specific manner.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Soon Sun Kim, Geum Ok Baek, Hye Ri Ahn, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Serum small extracellular vesicle-derived LINC00853 as a novel diagnostic marker for early hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Oncol (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/1878-0261.12745"}], "href": "https://doi.org/10.1002/1878-0261.12745"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32525601"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32525601"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Jingyuan Li, Jamal Muhammad, Tian Xie, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC00853 restrains T cell acute lymphoblastic leukemia invasion and infiltration by regulating CCR9/CCL25."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Immunol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.molimm.2021.10.016"}], "href": "https://doi.org/10.1016/j.molimm.2021.10.016"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34808497"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34808497"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Johnny T Y Kung, Jeannie T Lee "}, {"type": "b", "children": [{"type": "t", "text": "RNA in the loop."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Dev Cell (2013)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.devcel.2013.03.009"}], "href": "https://doi.org/10.1016/j.devcel.2013.03.009"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "23537627"}], "href": "https://pubmed.ncbi.nlm.nih.gov/23537627"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Ulf Andersson Ørom, Thomas Derrien, Malte Beringer, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long noncoding RNAs with enhancer-like function in human cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell (2010)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.cell.2010.09.001"}], "href": "https://doi.org/10.1016/j.cell.2010.09.001"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "20887892"}], "href": "https://pubmed.ncbi.nlm.nih.gov/20887892"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Dubravka Vučićević, Olivia Corradin, Evgenia Ntini, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long ncRNA expression associates with tissue-specific enhancers."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Cycle (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.4161/15384101.2014.977641"}], "href": "https://doi.org/10.4161/15384101.2014.977641"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "25607649"}], "href": "https://pubmed.ncbi.nlm.nih.gov/25607649"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Denise Thiel, Nataša Djurdjevac Conrad, Evgenia Ntini, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identifying lncRNA-mediated regulatory modules via ChIA-PET network analysis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "BMC Bioinformatics (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12859-019-2900-8"}], "href": "https://doi.org/10.1186/s12859-019-2900-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31142264"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31142264"}]}]}]}