{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Recent studies have highlighted distinct roles for long non‐coding RNAs in modulating disease processes. For example, while several lncRNAs have been implicated in immune modulation during fungal infections (e.g., vitamin‐regulated immunomodulatory lncRNAs in monocytes (1)) and in prognostic stratification for hepatocellular carcinoma (2), LINC00856 emerged as a notable genomic locus in the context of genetic influences on adiposity. In a genome‐wide association study of adult survivors of childhood acute lymphoblastic leukemia, a variant within LINC00856 (rs575792008) was identified as one of two novel loci significantly associated with adult body mass index, with evidence suggesting that therapeutic exposures, such as cranial radiation therapy, may modify its effect—potentially through epigenetic mechanisms like DNA methylation (3). These findings nominate LINC00856 as a candidate gene involved in the genetic regulation of adiposity in long‐term survivors and underscore its prospective utility for understanding treatment‐modified genetic risk factors.\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n [Citations:"}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": "]\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Konstantin Riege, Martin Hölzer, Tilman E Klassert, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Massive Effect on LncRNAs in Human Monocytes During Fungal and Bacterial Infections and in Response to Vitamins A and D."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/srep40598"}], "href": "https://doi.org/10.1038/srep40598"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28094339"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28094339"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Zhiqiao Zhang, Yanling Ouyang, Yiyan Huang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Comprehensive bioinformatics analysis reveals potential lncRNA biomarkers for overall survival in patients with hepatocellular carcinoma: an on-line individual risk calculator based on TCGA cohort."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Cell Int (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12935-019-0890-2"}], "href": "https://doi.org/10.1186/s12935-019-0890-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31312112"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31312112"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Melissa A Richard, Austin L Brown, John W Belmont, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Genetic variation in the body mass index of adult survivors of childhood acute lymphoblastic leukemia: A report from the Childhood Cancer Survivor Study and the St. Jude Lifetime Cohort."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/cncr.33258"}], "href": "https://doi.org/10.1002/cncr.33258"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33048379"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33048379"}]}]}]}