{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC00857 is a long non‑coding RNA that is frequently dysregulated across a broad spectrum of cancers, including lung adenocarcinoma, non‑small cell lung cancer, ovarian cancer, colorectal cancer, pancreatic cancer, bladder cancer, and hepatocellular carcinoma. Its aberrant overexpression in tumor tissues, relative to normal counterparts, is consistently associated with poor clinical outcomes and reduced overall survival."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "4"}]}, {"type": "t", "text": " Functional investigations have demonstrated that LINC00857 promotes tumor progression by enhancing cell proliferation, colony formation, migration, invasion, and by inhibiting apoptosis. In many studies, loss‐of‑function experiments via RNA interference have resulted in reduced tumor cell growth in vitro and diminished tumorigenesis in vivo."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}, {"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n Mechanistically, LINC00857 functions—at least in part—as a competitive endogenous RNA (ceRNA) that sequesters several microRNAs (including miR‑422a, miR‑486‑5p, miR‑1179, miR‑1306, miR‑150‑5p, miR‑340‑5p, and miR‑130b), thereby relieving repression of downstream oncogenic targets such as kallikrein‑related peptidase 4, YAP1, SPAG5, transforming growth factor α, claudin‑12, RHOA, CBX3, and vimentin."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}, {"type": "fg_fs", "start_ref": "6", "end_ref": "10"}]}, {"type": "t", "text": " In addition, LINC00857 has been implicated in the regulation of critical signaling pathways such as cell cycle control, glycolysis, and the NF‑κB/BIRC5 axis"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}, {"type": "fg_f", "ref": "11"}]}, {"type": "t", "text": ", and it can modulate gene expression through recruitment of transcription factors (e.g., TFAP2C, ZNF460) or splicing regulators (e.g., SRSF1) that further promote oncogenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "12"}, {"type": "fg_f", "ref": "10"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n \n "}, {"type": "p", "children": [{"type": "t", "text": "\n The oncogenic potential of LINC00857 is further underscored by its role in mediating resistance to chemotherapy, as evidenced by its ability to modulate gene networks—such as the negative regulation of LMAN1 in bladder cancer—that impact cisplatin sensitivity."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "13"}]}, {"type": "t", "text": " Collectively, evidence from diverse cancer models supports the candidacy of LINC00857 not only as a prognostic biomarker but also as a promising therapeutic target for intervention."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "4"}, {"type": "fg_f", "ref": "14"}, {"type": "fg_fs", "start_ref": "6", "end_ref": "8"}, {"type": "fg_f", "ref": "11"}, {"type": "fg_f", "ref": "9"}, {"type": "fg_f", "ref": "13"}, {"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Lihui Wang, Yanli He, Weijun Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Non-coding RNA LINC00857 is predictive of poor patient survival and promotes tumor progression via cell cycle regulation in lung cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.7203"}], "href": "https://doi.org/10.18632/oncotarget.7203"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26862852"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26862852"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Shao-Ping Zhu, Jun-Yu Wang, Xian-Guo Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long intergenic non-protein coding RNA 00858 functions as a competing endogenous RNA for miR-422a to facilitate the cell growth in non-small cell lung cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Aging (Albany NY) (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/aging.101171"}], "href": "https://doi.org/10.18632/aging.101171"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28177876"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28177876"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Xueke Lin, Dilu Feng, Ping Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA LINC00857 regulates the progression and glycolysis in ovarian cancer by modulating the Hippo signaling pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Med (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/cam4.3322"}], "href": "https://doi.org/10.1002/cam4.3322"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32918541"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32918541"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Yan Huang, Yuanyuan Lin, Xiangxiang Song, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC00857 contributes to proliferation and lymphomagenesis by regulating miR-370-3p/CBX3 axis in diffuse large B-cell lymphoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Carcinogenesis (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1093/carcin/bgab013"}], "href": "https://doi.org/10.1093/carcin/bgab013"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33657224"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33657224"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Chaofeng Xia, Xiao-Yu Zhang, Wenhui Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC00857 contributes to hepatocellular carcinoma malignancy via enhancing epithelial-mesenchymal transition."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Biochem (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcb.28074"}], "href": "https://doi.org/10.1002/jcb.28074"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30506763"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30506763"}]}, {"type": "r", "ref": 6, "children": [{"type": "t", "text": "Tingfu Li, Hongbo Zhao, Hua Zhou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LncRNA LINC00857 strengthens the malignancy behaviors of pancreatic adenocarcinoma cells by serving as a competing endogenous RNA for miR-340-5p to upregulate TGFA expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0247817"}], "href": "https://doi.org/10.1371/journal.pone.0247817"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33661995"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33661995"}]}, {"type": "r", "ref": 7, "children": [{"type": "t", "text": "Na Chang, Yayun Cui, Xue Liang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long Noncoding RNA LINC00857 Promotes Proliferation, Migration, and Invasion of Colorectal Cancer Cell through miR-1306/Vimentin Axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Comput Math Methods Med (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1155/2021/5525763"}], "href": "https://doi.org/10.1155/2021/5525763"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33833823"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33833823"}]}, {"type": "r", "ref": 8, "children": [{"type": "t", "text": "Jian Han, Peng Wang, Xin Xia, et al. "}, {"type": "b", "children": [{"type": "t", "text": "EGR1 promoted anticancer effects of Scutellarin via regulating LINC00857/miR-150-5p/c-Myc in osteosarcoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Mol Med (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/jcmm.16809"}], "href": "https://doi.org/10.1111/jcmm.16809"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34346162"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34346162"}]}, {"type": "r", "ref": 9, "children": [{"type": "t", "text": "Peng Chen, Zhirui Zeng, Jie Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long noncoding RNA LINC00857 promotes pancreatic cancer proliferation and metastasis by regulating the miR-130b/RHOA axis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cell Death Discov (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41420-022-01008-2"}], "href": "https://doi.org/10.1038/s41420-022-01008-2"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35418193"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35418193"}]}, {"type": "r", "ref": 10, "children": [{"type": "t", "text": "Yong Zhang, Yuan Fang, Lijie Ma, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC00857 regulated by ZNF460 enhances the expression of CLDN12 by sponging miR-150-5p and recruiting SRSF1 for alternative splicing to promote epithelial-mesenchymal transformation of pancreatic adenocarcinoma cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "RNA Biol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/15476286.2021.1992995"}], "href": "https://doi.org/10.1080/15476286.2021.1992995"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35442145"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35442145"}]}, {"type": "r", "ref": 11, "children": [{"type": "t", "text": "Fushi Han, Shusong Yang, Wei Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Silencing of lncRNA LINC00857 Enhances BIRC5-Dependent Radio-Sensitivity of Lung Adenocarcinoma Cells by Recruiting NF-κB1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Ther Nucleic Acids (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.omtn.2020.09.020"}], "href": "https://doi.org/10.1016/j.omtn.2020.09.020"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33251047"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33251047"}]}, {"type": "r", "ref": 12, "children": [{"type": "t", "text": "Wenqing Zhang, Kaiyue Ji, Congcong Min, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Oncogenic LINC00857 recruits TFAP2C to elevate FAT1 expression in gastric cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Sci (2023)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/cas.15394"}], "href": "https://doi.org/10.1111/cas.15394"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35524544"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35524544"}]}, {"type": "r", "ref": 13, "children": [{"type": "t", "text": "Aleksandra M Dudek, Jasmijn G M van Kampen, J Alfred Witjes, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC00857 expression predicts and mediates the response to platinum-based chemotherapy in muscle-invasive bladder cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Cancer Med (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/cam4.1570"}], "href": "https://doi.org/10.1002/cam4.1570"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29856124"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29856124"}]}, {"type": "r", "ref": 14, "children": [{"type": "t", "text": "Dongbing Zhou, Sijia He, Daquan Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC00857 promotes colorectal cancer progression by sponging miR-150-5p and upregulating HMGB3 (high mobility group box 3) expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bioengineered (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/21655979.2021.2003941"}], "href": "https://doi.org/10.1080/21655979.2021.2003941"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34753396"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34753396"}]}]}]}