{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC00858 is a long intergenic non‐coding RNA that is frequently upregulated in a broad range of human malignancies—including colorectal cancer"}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": ", non‐small cell lung cancer"}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "4", "end_ref": "6"}]}, {"type": "t", "text": ", colon cancer"}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "7", "end_ref": "10"}]}, {"type": "t", "text": ", gastric cancer"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "11"}, {"type": "fg_f", "ref": "9"}, {"type": "fg_f", "ref": "13"}]}, {"type": "t", "text": ", ovarian cancer"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "14"}]}, {"type": "t", "text": ", hepatocellular carcinoma"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "16"}]}, {"type": "t", "text": ", Wilms tumor"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "17"}]}, {"type": "t", "text": ", bladder cancer"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "18"}]}, {"type": "t", "text": ", osteosarcoma"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "19"}]}, {"type": "t", "text": ", and retinoblastoma."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "20"}]}, {"type": "t", "text": " Its overexpression in tumor tissues relative to adjacent normal specimens correlates with advanced clinical stage, lymphatic metastasis, and poor patient prognosis.\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Functionally, LINC00858 exerts potent oncogenic effects by promoting cell proliferation, migration, invasion, and epithelial–mesenchymal transition while suppressing apoptosis in both in vitro and in vivo models."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}, {"type": "fg_f", "ref": "4"}, {"type": "fg_f", "ref": "2"}, {"type": "fg_f", "ref": "5"}, {"type": "fg_f", "ref": "11"}, {"type": "fg_f", "ref": "14"}, {"type": "fg_f", "ref": "3"}, {"type": "fg_f", "ref": "17"}, {"type": "fg_f", "ref": "6"}, {"type": "fg_f", "ref": "15"}, {"type": "fg_f", "ref": "19"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Mechanistically, LINC00858 functions predominantly as a competing endogenous RNA (ceRNA), sequestering multiple microRNAs to deregulate downstream oncogenic effectors and signaling pathways. For example, by sponging miR‑22‑3p"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}, {"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": ", miR‑422a"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ", miR‑4766‑5p"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ", miR‑3182"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": ", miR‑134‑5p"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "14"}]}, {"type": "t", "text": ", miR‑363‑3p"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "12"}]}, {"type": "t", "text": ", miR‑25‑3p"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ", miR‑653‑5p"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "17"}]}, {"type": "t", "text": ", miR‑153‑3p"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "16"}]}, {"type": "t", "text": ", and miR‑139."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "19"}]}, {"type": "t", "text": "LINC00858 derepresses a variety of oncogenes—including YWHAZ, kallikrein‐related peptidase 4 (KLK4), serine/threonine kinase PAK2, WNK2, hepatocyte nuclear factor 4α (HNF4α), matrix metalloproteinase 2 (MMP2), SMAD family member 7 (SMAD7), RAD18, Rabl3, FOXP4, and CDK14—and modulates key signaling cascades such as the MAPK and STAT3/5 pathways."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "10"}, {"type": "fg_f", "ref": "21"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, the aberrant overexpression of LINC00858 and its multifaceted regulatory impacts on ceRNA networks and oncogenic signaling pathways underscore its pivotal role in tumor progression. 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