{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC00861 has emerged as a multifunctional long non‐coding RNA that appears to play diverse roles in human disease by modulating gene expression and influencing key signaling pathways. In cervical cancer, reduced expression of LINC00861 is associated with advanced disease stage, lymph node metastasis, and poor patient survival. Functional studies demonstrated that its overexpression suppresses cell proliferation, migration, invasion, and epithelial–mesenchymal transition through acting as a competing endogenous RNA that sponges miR‐513b‑5p, thereby upregulating PTEN and subsequently inhibiting the AKT/mTOR pathway."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In addition, genetic studies in eczema have identified novel common variants at the TRIB1/LINC00861 locus, implicating LINC00861 in the regulation of skin barrier function and/or immune responses."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Similarly, in non‐smoking chronic obstructive pulmonary disease, LINC00861 participates in a regulatory network with microRNAs and transcription factors, suggesting a role in modulating pulmonary inflammatory processes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n LINC00861 has also been identified as a prognostic biomarker in ovarian cancer, where its copy number variation and expression status correlate with patient outcomes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": " In Parkinson’s disease, alterations in LINC00861 expression within an lncRNA–mRNA co‐expression network point to an involvement in regulating immune responses, which may contribute to disease pathogenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In hepatocellular carcinoma, LINC00861 is included in DNA repair–associated and early recurrence prognostic signatures, suggesting that its deregulation may influence cell cycle processes and tumor aggressiveness"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": ";."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "7"}]}, {"type": "t", "text": " Finally, integrative analyses in breast cancer have revealed that LINC00861 may interact with established clinical biomarkers such as estrogen and progesterone receptors and receptor tyrosine‐protein kinase erbB‑2, thereby implicating it in the transcriptional regulatory networks that govern tumor behavior."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Taken together, these studies reveal that LINC00861 appears to function predominantly as a tumor suppressor or prognostic marker by modulating cell signaling pathways—including the PTEN/AKT/mTOR axis—and by participating in gene regulatory networks involved in immune response and cellular stress, with its dysregulation being associated with poor clinical outcomes across a range of diseases.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Hui Liu, Ling Zhang, Xiaoling Ding, et al. 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