{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Recent genomic investigations have begun to shed light on the potential regulatory roles of noncoding regions in complex traits. In one genome‐wide meta‐analysis of the sense of smell among aging populations, a novel region encompassing NR5A2 and LINC00862 was identified as significantly associated with olfactory function in African‐Americans (3). Although the mechanistic details remain to be fully elucidated, LINC00862—a long intergenic noncoding RNA—may contribute to the regulation of olfactory perception, an observation that is of particular interest given the established links between olfactory decline, aging, and prodromal symptoms of neurodegenerative diseases.\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n This finding complements other genomic studies that have explored diverse biological phenomena including drug‐induced metabolic alterations in patients with hypertension (1), hormone‐regulated gene expression implicated in hepatocellular carcinoma risk (2), and cellular responses in stromal cells exposed to heparin (5). Together with additional work characterizing gene regulation in various cellular contexts (4), these studies underscore the growing recognition that noncoding regions, such as LINC00862, represent an important regulatory layer influencing diverse physiological processes.\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Further functional characterization of LINC00862 is warranted to understand its potential role in modulating olfactory sensitivity and its implications for aging-related neurodegenerative conditions.\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Citations:."}, {"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "5"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Sonal Singh, Caitrin W McDonough, Yan Gong, et al. 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"}, {"type": "b", "children": [{"type": "t", "text": "Genome-Wide Association Analysis of the Sense of Smell in U.S. Older Adults: Identification of Novel Risk Loci in African-Americans and European-Americans."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Neurobiol (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12035-016-0282-8"}], "href": "https://doi.org/10.1007/s12035-016-0282-8"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "27878761"}], "href": "https://pubmed.ncbi.nlm.nih.gov/27878761"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Viviane Balloy, Remya Koshy, Lea Perra, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Bronchial Epithelial Cells from Cystic Fibrosis Patients Express a Specific Long Non-coding RNA Signature upon "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "Pseudomonas aeruginosa"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " Infection."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Cell Infect Microbiol (2017)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fcimb.2017.00218"}], "href": "https://doi.org/10.3389/fcimb.2017.00218"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "28611953"}], "href": "https://pubmed.ncbi.nlm.nih.gov/28611953"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Sandra Laner-Plamberger, Michaela Oeller, Rodolphe Poupardin, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Heparin Differentially Impacts Gene Expression of Stromal Cells from Various Tissues."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Sci Rep (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41598-019-43700-x"}], "href": "https://doi.org/10.1038/s41598-019-43700-x"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31076619"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31076619"}]}]}]}