{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Emerging evidence from recent studies highlights the potential utility of LINC00865 as a prognostic biomarker in cancer. In gastric cancer, a ferroptosis‐related lncRNA risk model was established that incorporated LINC00865 along with five other lncRNAs; this model successfully stratified patients into high‐ and low‐risk groups and was associated with several signaling pathways involved in tumor progression and immune cell infiltration (2). In a separate study focusing on advanced renal cell carcinoma, LINC00865 was one component of a nine‐lncRNA signature that predicted poorer overall survival in patients with stage IV, high‐grade tumors; pathway enrichment analyses suggested that these lncRNAs, including LINC00865, may be involved in the regulation of cell division, cell cycle processes, DNA damage responses, and cytokine modulation (3). Although a study of inflammatory responses through endotoxin challenge analyzed tissue‐specific lincRNA profiles in innate immunity (1), LINC00865 was not specifically highlighted in that context. Collectively, the findings from the cancer studies indicate that LINC00865 holds promise as a biomarker for oncologic outcomes and may participate in key regulatory processes within tumor biology (2,3)."}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Jane F Ferguson, Chenyi Xue, Yuanfeng Gao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Tissue-Specific Differential Expression of Novel Genes and Long Intergenic Noncoding RNAs in Humans With Extreme Response to Evoked Endotoxemia."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Circ Genom Precis Med (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1161/CIRCGEN.117.001907"}], "href": "https://doi.org/10.1161/CIRCGEN.117.001907"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30571184"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30571184"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Qingfang Yue, Jun Bai, Fei Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Novel classification and risk model based on ferroptosis-related lncRNAs to predict oncologic outcomes for gastric cancer patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Biochem Mol Toxicol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jbt.23052"}], "href": "https://doi.org/10.1002/jbt.23052"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35315178"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35315178"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Ning Li, Haiying Zhang, Keyao Hu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A novel long non-coding RNA-based prognostic signature for renal cell carcinoma patients with stage IV and histological grade G4."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Bioengineered (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1080/21655979.2021.1971022"}], "href": "https://doi.org/10.1080/21655979.2021.1971022"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34499010"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34499010"}]}]}]}