{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Recent studies have highlighted the multifaceted role of the long non‐coding RNA LINC00870 in diverse disease contexts. In maternal blood during the third trimester, decreased LINC00870 levels were found to be inversely correlated with EBF1 mRNA expression, with higher levels of LINC00870 being associated with an increased risk of spontaneous preterm birth (sPTB)."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In a separate investigation related to tuberculosis (TB), LINC00870 expression was significantly increased in peripheral blood mononuclear cells infected with Mycobacterium tuberculosis. Overexpression of LINC00870 in these cells shifted the immune cytokine balance by inhibiting Th1-secreted cytokines while promoting Th2-secreted cytokines, concomitant with activation of the JAK/STAT signaling pathway as evidenced by increased p-STAT5 and p-JAK2 protein levels. Furthermore, elevated levels of LINC00870 were observed in both sputum and plasma samples from patients with active TB and latent TB infection, with levels decreasing after three months of therapy, indicating its potential as a biomarker for TB diagnosis and treatment monitoring."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Guoli Zhou, Claudia Holzman, Bin Chen, et al. "}, {"type": "b", "children": [{"type": "t", "text": "EBF1-Correlated Long Non-coding RNA Transcript Levels in 3rd Trimester Maternal Blood and Risk of Spontaneous Preterm Birth."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Reprod Sci (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s43032-020-00320-5"}], "href": "https://doi.org/10.1007/s43032-020-00320-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32959224"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32959224"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Wang Jianfang, Wang Hui, Kang Le "}, {"type": "b", "children": [{"type": "t", "text": "LINC00870 regulates Th1/Th2 via the JAK/STAT pathway in peripheral blood mononuclear cells infected with Mycobacterium tuberculosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int Immunopharmacol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.intimp.2020.107188"}], "href": "https://doi.org/10.1016/j.intimp.2020.107188"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34407915"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34407915"}]}]}]}