{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n The long intergenic non‐coding RNA LINC00871—identified as part of the MIS18BP1/LINC00871 locus—was recently discovered in a genome‐wide association study of shoulder impingement and rotator cuff tears."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " Although its precise biological function was not elaborated upon in the study, the genetic association of this locus with rotator cuff disease suggests that LINC00871 may play a regulatory role in gene expression pathways relevant to tendon integrity, repair, and overall musculoskeletal health. This finding highlights the potential involvement of long non‐coding RNAs in modulating tissue structure and the pathologic processes underlying rotator cuff pathology, thereby supporting further investigation into its mechanistic contributions, as well as its possible utility as a biomarker for disease risk and a target for personalized therapeutic intervention.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Stuart K Kim, Condor Nguyen, Kevin B Jones, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A genome-wide association study for shoulder impingement and rotator cuff disease."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Shoulder Elbow Surg (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.jse.2020.11.025"}], "href": "https://doi.org/10.1016/j.jse.2020.11.025"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33482370"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33482370"}]}]}]}