{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC00877 is a long non‐coding RNA that has recently emerged as a candidate regulator in cancer, with evidence suggesting roles in both hematologic and neuroendocrine malignancies. While broad analyses have profiled numerous lncRNAs in diverse biological processes—ranging from human B‐cell development (1) and Th17 cell differentiation (2) to general mechanisms of gene regulation (3)—studies focused on malignant contexts have highlighted LINC00877 as particularly noteworthy. In acute myeloid leukemia, LINC00877 is among several lncRNAs whose expression differs across cytogenetic risk groups, implicating it as a potential biomarker for disease stratification and as a target for modulating leukemic cell behavior (4). Moreover, in pheochromocytomas and paragangliomas, reduced expression of LINC00877 has been validated in metastatic cases compared to non‐metastatic ones, suggesting that it may function as a tumor suppressor whose downregulation is associated with aggressive clinical outcomes (5). Together, these findings support further investigation into the molecular functions and mechanistic roles of LINC00877 as a prognostic indicator and therapeutic target in cancer."}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "5"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Andreas Petri, Karen Dybkær, Martin Bøgsted, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long Noncoding RNA Expression during Human B-Cell Development."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "PLoS One (2015)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1371/journal.pone.0138236"}], "href": "https://doi.org/10.1371/journal.pone.0138236"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26394393"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26394393"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Soile Tuomela, Sini Rautio, Helena Ahlfors, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Comparative analysis of human and mouse transcriptomes of Th17 cell priming."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncotarget (2016)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/oncotarget.7963"}], "href": "https://doi.org/10.18632/oncotarget.7963"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "26967054"}], "href": "https://pubmed.ncbi.nlm.nih.gov/26967054"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Amanda Salviano-Silva, Sara Cristina Lobo-Alves, Rodrigo Coutinho de Almeida, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Besides Pathology: Long Non-Coding RNA in Cell and Tissue Homeostasis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Noncoding RNA (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/ncrna4010003"}], "href": "https://doi.org/10.3390/ncrna4010003"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29657300"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29657300"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Alina-Andreea Zimta, Ciprian Tomuleasa, Iman Sahnoune, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Long Non-coding RNAs in Myeloid Malignancies."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Oncol (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fonc.2019.01048"}], "href": "https://doi.org/10.3389/fonc.2019.01048"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31681586"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31681586"}]}, {"type": "r", "ref": 5, "children": [{"type": "t", "text": "Suman Ghosal, Boqun Zhu, Thanh-Truc Huynh, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A long noncoding RNA-microRNA expression signature predicts metastatic signature in pheochromocytomas and paragangliomas."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Endocrine (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1007/s12020-021-02857-0"}], "href": "https://doi.org/10.1007/s12020-021-02857-0"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34536193"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34536193"}]}]}]}