{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n In a comprehensive genome‐wide analysis designed to identify non‐coding driver mutations in cancer, a long intergenic non‐coding RNA—LINC00879—was pinpointed as one of 160 significant non‐coding elements showing recurrent mutations and features of evolutionary conservation and cancer specificity (1). The identification of LINC00879 through the novel two‐stage ncDriver procedure suggests that aberrations affecting this lincRNA may disrupt the regulation of gene expression, thereby contributing to cellular dysfunction and tumor development. In essence, LINC00879 is emerging as a candidate driver element in cancer, with its mutation profile hinting at a role in modulating clinical outcomes through altered regulatory mechanisms."}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Henrik Hornshøj, Morten Muhlig Nielsen, Nicholas A Sinnott-Armstrong, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Pan-cancer screen for mutations in non-coding elements with conservation and cancer specificity reveals correlations with expression and survival."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "NPJ Genom Med (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1038/s41525-017-0040-5"}], "href": "https://doi.org/10.1038/s41525-017-0040-5"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29354286"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29354286"}]}]}]}