LINC00880 Gene

Name long intergenic non-protein coding RNA 880
Summary
{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC00880 is a long non‐coding RNA that has been implicated in cancer biology. One study originally reported that LINC00880 promoted cell proliferation, migration, and invasion while inhibiting apoptosis in spinal cord ependymoma by modulating the MAPK signaling pathway via targeting CACNG5; however, this publication has been retracted due to concerns over data integrity."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In addition, an independent investigation in hepatocellular carcinoma patients with cirrhosis identified LINC00880 as one component of a four‐lncRNA risk scoring system capable of predicting overall survival. Functional enrichment analysis in this study suggested that the dysregulated lncRNAs—including LINC00880—may be associated with pathways such as Wnt signaling and cytokine–cytokine receptor interaction, pointing to a potential role in tumor progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Unknown Authors "}, {"type": "b", "children": [{"type": "t", "text": "Retraction."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Cell Physiol (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1002/jcp.30507"}], "href": "https://doi.org/10.1002/jcp.30507"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34287864"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34287864"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Jiaxiang Ye, Haixia Li, Jiazhang Wei, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Risk Scoring System based on lncRNA Expression for Predicting Survival in Hepatocellular Carcinoma with Cirrhosis."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Asian Pac J Cancer Prev (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.31557/APJCP.2020.21.6.1787"}], "href": "https://doi.org/10.31557/APJCP.2020.21.6.1787"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32592379"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32592379"}]}]}]}
NCBI Gene ID 339894
API
Download Associations
Predicted Functions View LINC00880's ARCHS4 Predicted Functions.
Co-expressed Genes View LINC00880's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View LINC00880's ARCHS4 Predicted Functions.

Functional Associations

LINC00880 has 172 functional associations with biological entities spanning 4 categories (chemical, disease, phenotype or trait, cell line, cell type or tissue, gene, protein or microRNA) extracted from 10 datasets.

Click the + buttons to view associations for LINC00880 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CCLE Cell Line Gene CNV Profiles cell lines with high or low copy number of LINC00880 gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.
COSMIC Cell Line Gene CNV Profiles cell lines with high or low copy number of LINC00880 gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.
GEO Signatures of Differentially Expressed Genes for Gene Perturbations gene perturbations changing expression of LINC00880 gene from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.
GEO Signatures of Differentially Expressed Genes for Kinase Perturbations kinase perturbations changing expression of LINC00880 gene from the GEO Signatures of Differentially Expressed Genes for Kinase Perturbations dataset.
GEO Signatures of Differentially Expressed Genes for Small Molecules small molecule perturbations changing expression of LINC00880 gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset.
GTEx Tissue Gene Expression Profiles tissues with high or low expression of LINC00880 gene relative to other tissues from the GTEx Tissue Gene Expression Profiles dataset.
GWAS Catalog SNP-Phenotype Associations phenotypes associated with LINC00880 gene in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of LINC00880 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
MotifMap Predicted Transcription Factor Targets transcription factors regulating expression of LINC00880 gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.
Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles cell types and tissues with high or low DNA methylation of LINC00880 gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles dataset.