{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Long intergenic non‐coding RNA 882 (LINC00882) has emerged as an important regulator in diverse pathological conditions by modulating key signaling pathways via its competing endogenous RNA functions. In pediatric asthma, LINC00882 is significantly up‐regulated in fetal airway smooth muscle cells upon PDGF stimulation, where it promotes cell proliferation by sponging microRNA‐3619‐5p and consequently enhancing Wnt/β‐catenin signaling."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In colorectal cancer, elevated expression of LINC00882 facilitates tumor progression by acting as a molecular sponge for microRNA‐3619‐5p, which leads to the up‐regulation of CTNNB1 and the promotion of cell migration and epithelial–mesenchymal transition."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " In hepatocellular carcinoma, LINC00882 is markedly overexpressed in tumor tissues and correlates with a poorer prognosis; functional studies revealed that knockdown of LINC00882 inhibits cancer cell proliferation, migration, and invasion. Moreover, LINC00882 transcription is activated by ATF2, and it further contributes to HCC progression by sponging microRNA‐214‐3p to enhance CENPM expression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these findings demonstrate that LINC00882 functions as an oncogenic regulator by modulating microRNA‐mediated signaling cascades in both respiratory and hepatic contexts; its role as a competing endogenous RNA suggests that it might serve as a promising therapeutic target and prognostic biomarker in these diseases.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Zengfang Liu, Linghua Mei, Zhaoping He "}, {"type": "b", "children": [{"type": "t", "text": "Long non-coding RNA00882 contributes to platelet-derived growth factor-induced proliferation of human fetal airway smooth muscle cells by enhancing Wnt/β-catenin signaling via sponging miR-3619-5p."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochem Biophys Res Commun (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.bbrc.2019.04.106"}], "href": "https://doi.org/10.1016/j.bbrc.2019.04.106"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31014672"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31014672"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Bingtan Song, Hesheng Li, Song Guo, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC00882 Plays a Tumor-promoter Role in Colorectal Cancer by Targeting miR-3619-5p to Up-regulate CTNNB1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Arch Med Res (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.arcmed.2021.06.001"}], "href": "https://doi.org/10.1016/j.arcmed.2021.06.001"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34399990"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34399990"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Lei Zhu, Feizhou Huang, Tao Wan, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Overexpression of long noncoding RNA "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "LINC00882"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " is associated with poor prognosis in hepatocellular carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Onco Targets Ther (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2147/OTT.S170825"}], "href": "https://doi.org/10.2147/OTT.S170825"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30271163"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30271163"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Hua Ren, Zhi-Cheng Wei, Yan-Xia Sun, et al. "}, {"type": "b", "children": [{"type": "t", "text": "ATF2-Induced Overexpression of lncRNA LINC00882, as a Novel Therapeutic Target, Accelerates Hepatocellular Carcinoma Progression "}, {"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "via"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " Sponging miR-214-3p to Upregulate CENPM."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Oncol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fonc.2021.714264"}], "href": "https://doi.org/10.3389/fonc.2021.714264"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34513693"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34513693"}]}]}]}