{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC00885 is a long intergenic non‐coding RNA that has emerged as an oncogenic regulator in multiple cancer types. Initial characterization (1) and subsequent studies in cervical cancer revealed that LINC00885 is markedly upregulated and plays a critical role in promoting tumor progression. In cervical cancer, increased expression of LINC00885 enhances cellular proliferation and invasion while inhibiting apoptosis. Mechanistic investigations have shown that LINC00885 predominantly localizes to the cytoplasm where it functions as a competitive endogenous RNA by binding miR‑3150b‑3p, thereby leading to the upregulation of BAZ2A—a process that facilitates tumor growth and survival (2, 3). Additionally, dysregulation of LINC00885 has also been observed in bladder cancer, where its expression is positively correlated with that of the transcription factor GATA3, further supporting its involvement in oncogenic signaling pathways (4). Collectively, these findings highlight the potential of LINC00885 as both a promising biomarker and a therapeutic target in various cancers."}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "4"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Martin C Abba, Romina Canzoneri, Agustina Gurruchaga, et al. "}, {"type": "b", "children": [{"type": "a", "children": [{"type": "t", "text": "i"}], "href": "i"}, {"type": "t", "text": "LINC00885"}, {"type": "a", "children": [{"type": "t", "text": "/i"}], "href": "/i"}, {"type": "t", "text": " a Novel Oncogenic Long Non-Coding RNA Associated with Early Stage Breast Cancer Progression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Int J Mol Sci (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3390/ijms21197407"}], "href": "https://doi.org/10.3390/ijms21197407"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33049922"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33049922"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Yawen Liu, Haiyan Tu, Lingling Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "FOXP3‑induced LINC00885 promotes the proliferation and invasion of cervical cancer cells."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Mol Med Rep (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/mmr.2021.12097"}], "href": "https://doi.org/10.3892/mmr.2021.12097"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33880574"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33880574"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Yeling Liu, Jingrui Chen, Lizhong Zhou, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC00885 promotes cervical cancer progression through sponging miR-3150b-3p and upregulating BAZ2A."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biol Direct (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s13062-021-00314-6"}], "href": "https://doi.org/10.1186/s13062-021-00314-6"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35012615"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35012615"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Mingshan Li, Yili Liu, Xiling Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Transcriptomic analysis of high-throughput sequencing about circRNA, lncRNA and mRNA in bladder cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Gene (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1016/j.gene.2018.07.041"}], "href": "https://doi.org/10.1016/j.gene.2018.07.041"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "30025927"}], "href": "https://pubmed.ncbi.nlm.nih.gov/30025927"}]}]}]}