{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC00887 has emerged as a multifaceted long non‐coding RNA with context‐dependent roles in cancer progression. In glioma, LINC00887 is upregulated and functions in a pro‐tumorigenic manner by positively regulating CCND1 expression, thereby promoting cell proliferation and correlating with a poorer overall survival outcome."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In nasopharyngeal carcinoma, increased levels of LINC00887 enhance cell proliferation through a regulatory loop in which LINC00887 acts as a molecular sponge for miRNA‑203b‑3p and upregulates NUP205."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " In adrenocortical carcinoma, LINC00887 has been identified among lncRNAs associated with prognosis, suggesting its potential value as a biomarker even though its mechanistic role requires further clarification."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Moreover, in tongue squamous carcinoma, alternative transcript variants of LINC00887 (887S and 887L) have been characterized. Under normoxic conditions the variants interact, but upon hypoxia they dissociate and function antagonistically on a common target, CA9, with one variant recruiting HIF1α to activate CA9 transcription and the other engaging DNMT1 to mediate CA9 promoter methylation, thereby fine‐tuning the tumor’s adaptive response to hypoxic stress."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In cervical cancer, LINC00887 acts as a tumor suppressor. Its overexpression inhibits cell proliferation and invasion by sponging miR‑454‑3p, which in turn leads to an upregulation of FRMD6 and activation of the Hippo signaling pathway."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "5"}]}, {"type": "t", "text": " In contrast, studies in lung carcinomas and non‐small cell lung cancer have shown that LINC00887 functions as an oncogenic factor; here it interacts with miR‑206 (and other microRNAs) to regulate targets such as NRP1, fibronectin 1, MET, and SMAD4, thereby facilitating cell migration, epithelial–mesenchymal transition, and the acquisition of stem cell–like properties."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "6"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Finally, in renal cell carcinoma, elevated levels of LINC00887 in both tumor tissue and patient serum correlate with enhanced cell proliferation and suggest its potential utility as a non‐invasive biomarker for early-stage disease."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "8"}]}, {"type": "t", "text": " Overall, depending on the tumor type, LINC00887 can either promote or inhibit malignant phenotypes through its roles as a competing endogenous RNA and by modulating specific downstream targets, highlighting its potential value as both a prognostic biomarker and a candidate for therapeutic intervention.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "X-M Shen, S Han, N Liu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC00887 aggravates the malignant progression of glioma via upregulating CCND1."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Rev Med Pharmacol Sci (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.26355/eurrev_202102_25091"}], "href": "https://doi.org/10.26355/eurrev_202102_25091"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33660802"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33660802"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "W-J Yue, Y Wang, W-Y Li, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC00887 regulates the proliferation of nasopharyngeal carcinoma via targeting miRNA-203b-3p to upregulate NUP205."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Eur Rev Med Pharmacol Sci (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.26355/eurrev_202009_22826"}], "href": "https://doi.org/10.26355/eurrev_202009_22826"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32964975"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32964975"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Yang Zhou, Xiao Wang, Xi Zhu, et al. 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