{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC00891 has emerged as a functionally significant long non‐coding RNA with context‐dependent roles in cancer. In lung adenocarcinoma, LINC00891 acts as a tumor suppressor; its expression is markedly downregulated in cancer tissues and cell lines, and forced overexpression impedes cell proliferation, invasion, migration, and the epithelial–mesenchymal transition (EMT). Mechanistic studies indicate that LINC00891 is transcriptionally regulated by the GATA2/miR‑128‑3p axis and functions, at least in part, by restraining the RhoA pathway, with its knockdown promoting xenograft tumor growth that can be countered by chemical inhibition of RhoA signaling."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In endometrial cancer, LINC00891 is one of several long intergenic non‑coding RNAs (lincRNAs) that display exquisite specificity for malignant endometrium compared to adjacent normal tissue and also distinguish endometrial cancer from other gynecologic malignancies. Although the mechanistic details in this context are not yet fully elucidated, its differential expression suggests a potential role as a diagnostic biomarker."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Broader studies in lung adenocarcinoma have identified panels of prognostic lncRNAs that are involved in lung cancer–related biological processes"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": ", while comprehensive reviews of non‑coding RNAs in various cancers underscore the emerging importance of lncRNAs and lincRNAs as regulators in oncogenesis."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Yunfeng Zhang, Dingli Song, Ziyang Peng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "LINC00891 regulated by miR-128-3p/GATA2 axis impedes lung cancer cell proliferation, invasion and EMT by inhibiting RhoA pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Acta Biochim Biophys Sin (Shanghai) (2022)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3724/abbs.2022005"}], "href": "https://doi.org/10.3724/abbs.2022005"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "35538035"}], "href": "https://pubmed.ncbi.nlm.nih.gov/35538035"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Bei Jun Chen, Frances L Byrne, Konii Takenaka, et al. 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