{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n Recent studies have identified the long non‐coding RNA LINC00892 as a component of multiple prognostic signatures associated with tumor immune infiltration, microenvironment regulation, and hypoxic response in cancer. In non‐small cell lung cancer, LINC00892 was among a set of lncRNAs that helped stratify patients based on immune cell infiltration, thereby indirectly linking its expression to improved clinical outcomes and potentially to a more favorable response to immunotherapy."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": " In bladder cancer, LINC00892 has been included in risk score models based on tumor microenvironment‐associated lncRNAs, where its negative coefficient suggests that higher expression may be protective and associated with less aggressive disease progression."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": " Moreover, LINC00892 has been identified as one of four hypoxia‐related lncRNAs that contribute to a molecular subtype predictive of patient prognosis, correlating with variations in immune checkpoint expression and chemotherapeutic sensitivity."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": " Additional work exploring immune-related lncRNA signatures in bladder cancer further supports the notion that LINC00892 is a promising immuno-biomarker that may improve risk stratification and help predict responses to immunotherapy."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": "\n "}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Collectively, these findings suggest that while the precise mechanistic role of LINC00892 remains to be fully elucidated, its inclusion in various prognostic models underscores its potential in modulating the tumor immune microenvironment. Consequently, LINC00892 may serve as a valuable predictive marker to guide personalized cancer therapies.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Jie Sun, Zicheng Zhang, Siqi Bao, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of tumor immune infiltration-associated lncRNAs for improving prognosis and immunotherapy response of patients with non-small cell lung cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Immunother Cancer (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1136/jitc-2019-000110"}], "href": "https://doi.org/10.1136/jitc-2019-000110"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32041817"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32041817"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Gaoteng Lin, Baoyin Guo, Yulei Wei, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Impact of Long Non-coding RNAs Associated With Microenvironment on Survival for Bladder Cancer Patients."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Genet (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fgene.2020.567200"}], "href": "https://doi.org/10.3389/fgene.2020.567200"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33281872"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33281872"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Xianwu Chen, Yan Zhang, Feifan Wang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A Novel Assessment Model Based on Molecular Subtypes of Hypoxia-Related LncRNAs for Prognosis of Bladder Cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Cell Dev Biol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fcell.2021.718991"}], "href": "https://doi.org/10.3389/fcell.2021.718991"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34869309"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34869309"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Yucai Wu, Lei Zhang, Shiming He, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Identification of immune-related LncRNA for predicting prognosis and immunotherapeutic response in bladder cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Aging (Albany NY) (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.18632/aging.104115"}], "href": "https://doi.org/10.18632/aging.104115"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "33221763"}], "href": "https://pubmed.ncbi.nlm.nih.gov/33221763"}]}]}]}