{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC00894 has been implicated in cancer through distinct molecular mechanisms. In kidney renal papillary cell carcinoma (KIRP) and lung adenocarcinoma (LUAD), LINC00894 is part of a competitive endogenous RNA (ceRNA) network that includes MMP25‐AS1, SNHG1, LINC02298, and MIR193BHG, which functions to sponge miR‑140‑3p and thereby modulate the expression of GPRIN1. This regulatory axis is associated with an increased expression of GPRIN1, altered tumor immune cell infiltration, and poor clinical outcomes."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n In the context of breast cancer, particularly in estrogen receptor‐positive cases undergoing tamoxifen treatment, an isoform designated LINC00894‑002 is found to be downregulated in tamoxifen‑resistant (TamR) cells. Directly upregulated by ERα, LINC00894‑002 normally acts to maintain the levels of miR‑200a‑3p and miR‑200b‑3p. Its loss leads to the upregulation of TGF‑β2 and ZEB1, resulting in enhanced tamoxifen resistance."}, {"type": "fg", "children": [{"type": "fg_f", "ref": "2"}]}, {"type": "t", "text": ""}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "t", "text": "\n Although additional studies have highlighted the regulatory roles of long non‑coding RNAs in tumorigenesis"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "3"}]}, {"type": "t", "text": "and provided further insights into lncRNA network complexity"}, {"type": "fg", "children": [{"type": "fg_f", "ref": "4"}]}, {"type": "t", "text": ", the findings described above underscore that LINC00894 functions in a context‑dependent manner. It participates in oncogenic ceRNA mechanisms in certain carcinomas while acting as an inhibitor of drug resistance in breast cancer.\n "}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Qiwei Zhou, Diangeng Li, Hongying Zheng, et al. "}, {"type": "b", "children": [{"type": "t", "text": "A novel lncRNA-miRNA-mRNA competing endogenous RNA regulatory network in lung adenocarcinoma and kidney renal papillary cell carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Thorac Cancer (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1111/1759-7714.14129"}], "href": "https://doi.org/10.1111/1759-7714.14129"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34453499"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34453499"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Xiulei Zhang, Meiting Wang, Huihui Sun, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Downregulation of LINC00894-002 Contributes to Tamoxifen Resistance by Enhancing the TGF-β Signaling Pathway."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Biochemistry (Mosc) (2018)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1134/S0006297918050139"}], "href": "https://doi.org/10.1134/S0006297918050139"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "29738694"}], "href": "https://pubmed.ncbi.nlm.nih.gov/29738694"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "De-Feng Meng, Hua Shao, Chuan-Bo Feng "}, {"type": "b", "children": [{"type": "t", "text": "LINC00894 Enhances the Progression of Breast Cancer by Sponging miR-429 to Regulate ZEB1 Expression."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Onco Targets Ther (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.2147/OTT.S277284"}], "href": "https://doi.org/10.2147/OTT.S277284"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34079285"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34079285"}]}, {"type": "r", "ref": 4, "children": [{"type": "t", "text": "Lugang Deng, Peixi Wang, Zhi Qu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "The Construction and Analysis of ceRNA Network and Immune Infiltration in Kidney Renal Clear Cell Carcinoma."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Genet (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fgene.2021.667610"}], "href": "https://doi.org/10.3389/fgene.2021.667610"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34567057"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34567057"}]}]}]}