{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC00896 is a long non‐coding RNA that appears to be involved in diverse pathological settings. In the context of Chromosome 22q11.2 deletion syndrome, loss of non‐coding RNAs—including LINC00896 as part of the ~106 gene set lost—may contribute to the complex developmental and multi‐organ defects associated with the syndrome (1). In colon adenocarcinoma, LINC00896 was identified as one of a six‐lncRNA signature associated with genomic instability. Its dysregulated expression correlates with increased levels of PD-L1 and higher somatic mutation rates, suggesting that LINC00896 may serve not only as a prognostic biomarker but also as an indicator for potential sensitivity to immunotherapy (2). In lung squamous cell carcinoma, integration of transcriptomic and copy number variation data highlighted LINC00896 among several lncRNAs regulated by non‐coding genomic variations, proposing its utility as a biomarker for disease prognosis and as a candidate for further exploration in targeted therapeutic strategies (3)."}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "fg", "children": [{"type": "fg_fs", "start_ref": "1", "end_ref": "3"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Qiumei Du, M Teresa de la Morena, Nicolai S C van Oers "}, {"type": "b", "children": [{"type": "t", "text": "The Genetics and Epigenetics of 22q11.2 Deletion Syndrome."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Genet (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fgene.2019.01365"}], "href": "https://doi.org/10.3389/fgene.2019.01365"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32117416"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32117416"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Shujia Chen, Xiaofei Li, Jiachen Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Six mutator-derived lncRNA signature of genome instability for predicting the clinical outcome of colon cancer."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "J Gastrointest Oncol (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.21037/jgo-21-494"}], "href": "https://doi.org/10.21037/jgo-21-494"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34790382"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34790382"}]}, {"type": "r", "ref": 3, "children": [{"type": "t", "text": "Jinfeng Ning, Fengjiao Wang, Kaibin Zhu, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Characterizing the Copy Number Variation of Non-Coding RNAs Reveals Potential Therapeutic Targets and Prognostic Markers of LUSC."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Front Genet (2021)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3389/fgene.2021.779155"}], "href": "https://doi.org/10.3389/fgene.2021.779155"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "34925461"}], "href": "https://pubmed.ncbi.nlm.nih.gov/34925461"}]}]}]}