{"type": "root", "children": [{"type": "p", "children": [{"type": "t", "text": "\n LINC00898 appears to be one of several long non‐coding RNAs that contribute to epigenetic regulation in distinct pathological contexts. In a study of colon adenocarcinoma, lncRNAs were comprehensively profiled using a LASSO‐based approach. Within this framework, LINC00898 is implicated in the regulation of gene expression networks that can affect tumor progression and patient overall survival, supporting its potential utility in prognostic prediction of disease outcome (1). In a separate investigation focused on cryptorchidism, treatment with a gonadotropin releasing hormone agonist was shown to modulate testicular lncRNA levels. Given that certain lncRNAs interact with chromatin‐modifying enzymes to drive epigenetic changes, LINC00898 may similarly be involved in triggering the differentiation of Ad spermatogonia via an epigenetic mechanism that mimics the effects of mini‐puberty; this provides molecular insight into the observed infertility issues associated with cryptorchidism (2). Collectively, these studies highlight LINC00898 as a potential epigenetic regulator that may influence both cancer pathogenesis and the proper development of germ cells."}]}, {"type": "t", "text": "\n "}, {"type": "p", "children": [{"type": "fg", "children": [{"type": "fg_f", "ref": "1"}]}, {"type": "t", "text": ""}]}, {"type": "rg", "children": [{"type": "r", "ref": 1, "children": [{"type": "t", "text": "Qiongying Zhang, Zhuo Lin, Haiyan Zhang, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Prediction of overall survival time in patients with colon adenocarcinoma using DNA methylation profiling of long non-coding RNAs."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Oncol Lett (2020)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.3892/ol.2019.11236"}], "href": "https://doi.org/10.3892/ol.2019.11236"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "32002035"}], "href": "https://pubmed.ncbi.nlm.nih.gov/32002035"}]}, {"type": "r", "ref": 2, "children": [{"type": "t", "text": "Faruk Hadziselimovic, Gilvydas Verkauskas, Beata Vincel, et al. "}, {"type": "b", "children": [{"type": "t", "text": "Testicular expression of long non-coding RNAs is affected by curative GnRHa treatment of cryptorchidism."}]}, {"type": "t", "text": " "}, {"type": "i", "children": [{"type": "t", "text": "Basic Clin Androl (2019)"}]}, {"type": "t", "text": " DOI: "}, {"type": "a", "children": [{"type": "t", "text": "10.1186/s12610-019-0097-3"}], "href": "https://doi.org/10.1186/s12610-019-0097-3"}, {"type": "t", "text": " PMID: "}, {"type": "a", "children": [{"type": "t", "text": "31890219"}], "href": "https://pubmed.ncbi.nlm.nih.gov/31890219"}]}]}]}